Anti-inflammatory effect of sulodexide during acute peritonitis in rats

Blood Purification
Jacek KarońAndrzej Breborowicz

Abstract

Peritonitis is one of the complications of peritoneal dialysis. We demonstrate the systemic and intraperitoneal anti-inflammatory action of sulodexide given systemically. Dialysis was performed in male Wistar rats with acute peritonitis induced by addition of endotoxin to the fluid. Sulodexide (10 mg/kg b.w.) was used acutely as supplement to the dialysis fluid or chronically, during 7 days preceding the study by intramuscular (i.m.) injection. In rats given i.m. sulodexide the dialysate cell count was lower by 45% (p < 0.001) versus untreated rats with peritonitis. Dialysate elastase activity in i.m. sulodexide-treated rats was lower by 22% (p < 0.05) compared to peritonitis. In rats treated with i.m. sulodexide the increase of plasma tumor necrosis factor-alpha was reduced by 53% (p < 0.002). Pretreatment with i.m. sulodexide reduced transperitoneal loss of total protein and albumin during peritonitis by 26% (p < 0.002) and by 16% (p < 0.05), respectively. Sulodexide given systemically reduces the intraperitoneal and vascular inflammatory response during acute peritonitis in rats.

References

Jan 1, 1985·The Journal of International Medical Research·C CorsiE Marrapodi
Feb 1, 1993·The Journal of Pharmacy and Pharmacology·M AkatsukaT Ando
May 14, 1998·Seminars in Thrombosis and Hemostasis·F A Ofosu
Jan 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A FracassoG Gambaro
Mar 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A BreborowiczD Oreopoulos
May 16, 2002·Chest·Teresa D Tetley
Oct 19, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roberto Pecoits-FilhoPeter Stenvinkel
Sep 15, 2004·The Journal of Pharmacology and Experimental Therapeutics·D Adam LauverBenedict R Lucchesi
Apr 26, 2005·Nephron. Clinical Practice·Jonas Angel SjølandJørgen Gram
Aug 2, 2006·Treatments in Endocrinology·Cataldo Abaterusso, Giovanni Gambaro

❮ Previous
Next ❯

Citations

May 5, 2012·Acta Pharmacologica Sinica·Ping LiXiang-mei Chen
Jul 14, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anneleen PletinckWim Van Biesen
Apr 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Katarzyna Suminska-JasinskaAndrzej Breborowicz
Jan 1, 2010·International Journal of Nephrology and Renovascular Disease·Antonio V GaddiGiovanni Gambaro
Feb 15, 2012·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Giuseppe Maria Andreozzi
Nov 1, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Sijiao ChenDaoyan Liu
Jan 15, 2014·Advances in Medical Sciences·A PołubińskaA Bręborowicz
Feb 17, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Marta CiszewiczAndrzej Breborowicz
Aug 19, 2015·Journal of Clinical Pharmacy and Therapeutics·P Ditsawanon, P Aramwit
Jan 30, 2013·European Journal of Internal Medicine·Margien G S BoelsTon J Rabelink
Jun 3, 2016·The Cochrane Database of Systematic Reviews·Bin WuTing Xu
Aug 26, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Cafer AdiguzelJawed Fareed
Aug 15, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Raina RamnathSimon C Satchell
Jun 8, 2018·International Journal of Molecular Sciences·Armando Mansilha, Joel Sousa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Translational Research : the Journal of Laboratory and Clinical Medicine
Marta CiszewiczAndrzej Breborowicz
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Michele RossiniAgnes B Fogo
Seminars in Thrombosis and Hemostasis
F A Ofosu
Cardiovascular Drug Reviews
D Adam Lauver, Benedict R Lucchesi
© 2021 Meta ULC. All rights reserved