Abstract
Mistletoe has been used as the herbal medicine to treat hypertension, diabetes mellitus, inflammation, arthritis and viral infection. In this study, we evaluated the anti-inflammatory effect of extracts of branch from Taxillus yadoriki being parasitic in Neolitsea sericea (TY-NS-B) using in vitro model. TY-NS-B significantly inhibited LPS-induced secretion of NO and PGE2 in RAW264.7 cells. TY-NS-B was also observed to inhibit LPS-mediated iNOS COX-2 expression. In addition, TY-NS-B attenuated production of inflammatory cytokines such as TNF-α and IL-1β induced by LPS. TY-NS-B blocked LPS-mediated inhibitor of IκB-α, and inhibited p65 translocation to the nucleus and NF-κB activation. Furthermore, TY-NS-B reduced the phosphorylation of MAPKs such as p38 and JNK, but not ERK1/2. In addition, TY-NS-B increased ATF3 expression and ATF3 knockdown by ATF3 siRNA attenuated TY-NS-B-mediated inhibition of pro-inflammatory mediator expression. Collectively, our results suggest that TY-NS-B exerts potential anti-inflammatory effects by suppressing NF-κB and MAPK signaling activation, and increasing ATF3 expression. These findings indicate that TY-NS-B could be further developed as an anti-inflammatory drug.
References
Oct 4, 1996·Cell·P A Baeuerle, D Baltimore
Aug 14, 1999·Immunology·C ChenW W Lin
Aug 3, 2001·Gene·T Hai, M G Hartman
Aug 17, 2005·Current Drug Targets. Inflammation and Allergy·Tsuyoshi KasamaSteven L Kunkel
Apr 29, 2006·International Immunopharmacology·Riina NieminenEeva Moilanen
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyeonjoo CheonJong Dae Ji
Jul 24, 2007·Journal of Ethnopharmacology·Chang Hwa JungSeong-Gyu Ko
Dec 28, 2007·Clinical Chemistry·René R S Packard, Peter Libby
Oct 2, 2009·Clinical and Experimental Immunology·O J BroomO H Nielsen
Apr 21, 2010·Cardiovascular Toxicology·Yujuan ShanShuran Wang
Apr 24, 2010·Cancer Metastasis Reviews·Graziella SolinasPaola Allavena
Jul 12, 2011·Expert Reviews in Molecular Medicine·Timothy J Koh, Luisa Ann DiPietro
Dec 27, 2011·International Immunopharmacology·Anlys OliveraThaddeus W W Pace
Mar 23, 2012·Immunological Reviews·Thorsten GantkeSteven C Ley
Jul 31, 2013·Inflammation·Guan-Wei FanXiumei Gao
Sep 26, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Pei-Fang LaiSung-Ho Chen
Oct 24, 2013·Veterinary Immunology and Immunopathology·Yu TamuraMitsuyoshi Takiguchi
Apr 29, 2014·Inflammation & Allergy Drug Targets·Paul R BockKurt S Zänker
Jun 25, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Ki-Wook KimJong-Bae Kim
Jun 29, 2014·The Journal of Biological Chemistry·Juyoung KimHyae Gyeong Cheon
Aug 22, 2014·Biomolecules & Therapeutics·Byoung Ok ChoIl Yun Jeong
Apr 4, 2015·Explore : the Journal of Science and Healing·Richard Glickman-Simon, Jessie Pettit
Sep 29, 2015·Scientific Reports·Ji-Woong KwonSangdun Choi
Nov 10, 2015·Mediators of Inflammation·Caigan DuTheodore Steiner
Feb 18, 2016·International Journal of Biological Macromolecules·Zheng-Shun WenYou-Le Qu
Jul 7, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Young-An Bae, Hyae Gyeong Cheon
Oct 27, 2016·Placenta·Ratana LimMartha Lappas
Nov 24, 2016·Experimental and Molecular Pathology·Hong YeA Bennett Jenson
Jul 26, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Seul Ah LeeChun Sung Kim
Aug 30, 2017·Journal of Ethnopharmacology·Yi-Hong ZouGui-Hua Tang
Citations
Feb 9, 2019·Natural Product Research·Qing-Mei FengYue-Hu Pei
Feb 28, 2020·Experimental and Therapeutic Medicine·Seong Min KimGon Sup Kim
May 11, 2020·Aging·Yuwei ZhangBo Xiong
Jun 7, 2019·Chinese Journal of Natural Medicines·Shao-Peng HuangYing Liu
Apr 2, 2021·Plant Physiology·Jakub TěšitelDavid M Watson
Jul 27, 2021·Journal of Immunology Research·Soo-Min HaMin-Seong Ha
Aug 28, 2021·International Journal of Molecular Sciences·Hun Hwan KimGon Sup Kim