Anti-inflammatory effect of triterpene 3β, 6β, 16β-trihydroxylup-20(29)-ene obtained from Combretum leprosum Mart & Eich in mice

Journal of Ethnopharmacology
Daniela T Longhi-BalbinotAdair Roberto Soares Santos

Abstract

The 3β, 6β, 16β-trihydroxylup-20(29)-ene (TTHL) is a pentacyclic triterpene obtained from a medicinal plant named Combretum leprosum. In folk medicine, this plant is used to treat several diseases associated with inflammation and pain. We previously demonstrated that TTHL presents a significant antinociceptive effect, suggesting the involvement of the glutamatergic system. This study was designed to investigate the effect of TTHL on nociception and vascular permeability induced by acetic acid. We also evaluated the effect of TTHL on carrageenan-induced peritonitis and the levels of cytokines (interleukin 1-β [IL-1β], tumor necrosis factor α [TNF-α] and interleukin 10 [IL-10]) on peritoneal fluid. TTHL was administered orally by intra-gastric gavage (i.g.) 60 min prior to experimentation. Abdominal contractions and vascular permeability were induced by an intraperitoneal (i.p.) injection of acetic acid (0.6%). We also investigated whether TTHL decreases carrageenan-induced peritonitis (750 μg/cavity) by measuring leukocyte migration and vascular permeability. In addition, we evaluated the effects of TTHL on TNF-α, IL-1β and IL-10 release induced by carrageenan on peritoneal fluid. The levels of these cytokines were measured by E...Continue Reading

References

Oct 12, 1992·Neuroscience Letters·K A Sluka, K N Westlund
Mar 1, 1991·Arthritis and Rheumatism·A K JonesE C Huskisson
Sep 10, 1987·The New England Journal of Medicine·H L Malech, J I Gallin
Feb 1, 1968·British Journal of Pharmacology and Chemotherapy·H O CollierC Schneider
Jan 22, 1998·Planta medica·H Safayhi, E R Sailer
Apr 3, 2001·Journal of Ethnopharmacology·L J McGawJ van Staden
May 30, 2001·Journal of Ethnopharmacology·T Geetha, P Varalakshmi
Nov 20, 2001·Current Opinion in Pharmacology·S M Carlton
Oct 25, 2002·Mediators of Inflammation·Rosana L PaganoRenata Giorgi
Feb 28, 2003·Anesthesiology·Yi FengWilliam D Willis
Jun 5, 2003·Fitoterapia·V B CostaP D Fernandes
Dec 23, 2003·The International Journal of Biochemistry & Cell Biology·Susan E Sweeney, Gary S Firestein
Jul 25, 2006·Transplant Immunology·Robson PereiraTânia Silvia Fröde
Sep 5, 2006·Journal of Ethnopharmacology·Ana Beatriz MontanherTânia Silvia Fröde
Mar 14, 2007·Journal of Ethnopharmacology·Greice M R S LucenaAdair R S Santos
May 12, 2009·Journal of Ethnopharmacology·Hussain ZeashanSatyawan Singh
May 22, 2010·The Journal of Pain : Official Journal of the American Pain Society·Leidiane Mazzardo-MartinsAdair Roberto Soares Santos
Dec 25, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L S LopesF R C Almeida
Jul 30, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Morgana Duarte da SilvaAdair Roberto Soares Santos

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Citations

Oct 8, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Flávia Raquel Santos LucenaSilene C Nascimento
Feb 24, 2016·Journal of Ethnopharmacology·Faheema SiddiquiAhsana Dar Farooq
Mar 10, 2016·BMC Complementary and Alternative Medicine·Basile Nganmegne PiegangTélesphore Benoît Nguelefack
May 23, 2013·Basic & Clinical Pharmacology & Toxicology·Lucindo J Quintans-JúniorAdriano A S Araújo
Jun 22, 2014·Journal of Ethnopharmacology·Fabrício F A FernandesPaulo A Melo
Feb 13, 2013·Carbohydrate Polymers·Nessana DartoraGuilherme L Sassaki
Aug 2, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Cassiana Macagnan ViauJenifer Saffi
Oct 19, 2016·Immunopharmacology and Immunotoxicology·Feng XuNan Zeng
Nov 16, 2017·International Journal of Molecular Sciences·Maíra Conceição Jerônimo de Souza LimaMatheus de Freitas Fernandes-Pedrosa
Apr 4, 2017·TheScientificWorldJournal·Maria Christina Dos Santos VerdamObdulio Gomes Miguel
Jan 27, 2021·Journal of Toxicology and Environmental Health. Part a·Herbert Gonzaga SousaElcilene Alves de Sousa
Sep 24, 2020·Biochemical and Biophysical Research Communications·Francisca Crislândia Oliveira SilvaHélcio Silva Dos Santos
Aug 27, 2021·Journal of Biomolecular Structure & Dynamics·José Ismael F de AraújoHélcio S Dos Santos

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