Anti-inflammatory effects of a novel non-antibiotic macrolide, EM900, on mucus secretion of airway epithelium

Auris, Nasus, Larynx
Ichiro TojimaTakeshi Shimizu

Abstract

Low-dose, long-term use of 14-membered macrolides is effective for treatment of patients with chronic airway inflammation such as diffuse panbronchiolitis or chronic rhinosinusitis. However, long-term use of macrolides can promote the growth of drug-resistant bacteria, and the development of anti-inflammatory macrolides that lack antibiotic effects is desirable. Previously, we developed EM900, a novel 12-membered erythromycin A derivative, which has potent anti-inflammatory and immunomodulatory activities and lacks any antibacterial activity. We examined the anti-inflammatory effects of EM900 on mucus secretion from airway epithelial cells. To examine the in vivo effects of EM900 on airway inflammation, we induced hypertrophic and metaplastic changes of goblet cells in rat nasal epithelium via intranasal instillation of lipopolysaccharides. In vitro effects of EM900 on airway epithelial cells were examined using cultured human airway epithelial (NCI-H292) cells. Mucus secretion was evaluated via enzyme-linked immunosorbent assays with an anti-MUC5AC monoclonal antibody. Oral administration of EM900 or clarithromycin (CAM) significantly inhibited LPS-induced mucus production from rat nasal epithelium. EM900, CAM, or erythromycin...Continue Reading

References

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Citations

Oct 7, 2015·Auris, Nasus, Larynx·Takeshi Shimizu, Harumi Suzaki
Dec 30, 2016·Therapeutic Advances in Respiratory Disease·Shilin Qiu, Xiaoning Zhong
Jul 6, 2017·Allergy, Asthma & Immunology Research·Sung Woo Cho, Dong Young Kim
Nov 23, 2018·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Nozomu WakayamaSatoshi Ōmura
Dec 11, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hironori SadamatsuNaoko Sueoka-Aragane
Aug 3, 2019·The Veterinary Record·Sophie Mainguy-SeersJean-Pierre Lavoie
Sep 4, 2019·Respiration; International Review of Thoracic Diseases·Stephan F van Eeden, James C Hogg

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