Anti-inflammatory Effects of Achillea millefolium on Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

The American Journal of Chinese Medicine
Hien T T NgoTae-Hoo Yi

Abstract

Achillea millefolium L. (AM) is an aromatic herb with a variety of pharmacological properties, such as anti-inflammatory and anti-allergic activities. However, AM's effects on atopic dermatitis (AD) have not been investigated. This study evaluates the anti-AD activity of 50% ethanol-extracted AM in murine macrophage Raw 264.7 cells, in tumor necrosis factor-alpha/interferon-gamma (TNF-[Formula: see text]/IFN-[Formula: see text])-stimulated human immortal keratinocyte HaCaT cells in vitro, and in Biostir-AD-treated NC/Nga mice in vivo. The results showed that AM significantly downregulated expression of pro-inflammatory cytokines, such as INOS, COX-2, and interleukin (IL)-6 in lipopolysaccharide (LPS)-treated Raw 264.7 cells. The mRNA expressions of INOS, COX-2, and IL-6 decreased by 76.1%, 69.3%, and 31.8%, respectively. Overexpression of chemokines, such as activation-regulated chemokine and macrophage-derived chemokine, regulated on activation of normal T-cell expressed and secreted, and IL-8 was inhibited by 70.01%, 52.91%, 73.53%, and 18.93%, respectively, in TNF-[Formula: see text]/IFN-[Formula: see text]-stimulated HaCaT cells by downregulating the mitogen-activated protein kinase, I[Formula: see text]B[Formula: see text]...Continue Reading

References

Mar 19, 2003·The Journal of Allergy and Clinical Immunology·Takashi KakinumaKunihiko Tamaki
Sep 26, 2003·Journal of Dermatological Science·Hironori MatsushimaShinji Shimada
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Bernhard HomeyDonald Y M Leung
Dec 17, 2008·Current Pharmaceutical Design·E Nemeth, J Bernath
May 24, 2012·Journal of Allergy·Mary Beth HoganNevin W Wilson
Jan 30, 2013·Biotechnology for Biofuels·Leif J JönssonNils-Olof Nilvebrant
Jun 14, 2013·Experimental Biology and Medicine·Jin Kyeong Choi, Sang-Hyun Kim
Nov 13, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hye-Sun LimHyeun-Kyoo Shin
Nov 26, 2014·Pediatrics·Megha M TollefsonUNKNOWN Section On Dermatology
Feb 10, 2017·Journal of Ethnopharmacology·Majid MohammadhosseiniAbolfazl Akbarzadeh
Apr 3, 2018·Contact Dermatitis·Maryam SoltanipoorIrena Angelova-Fischer
Mar 25, 2019·International Journal of Molecular Sciences·Min Cheol KangSun Yeou Kim
Apr 8, 2019·The Journal of Allergy and Clinical Immunology·Emma Guttman-YasskyJames G Krueger

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Citations

Apr 10, 2021·Oxidative Medicine and Cellular Longevity·Marcelina Strzępek-GomółkaWirginia Kukula-Koch
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nhung Quynh DoTae-Hoo Yi

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