PMID: 9167214Apr 1, 1997Paper

Anti-inflammatory effects of beraprost sodium, a stable analogue of PGI2, and its mechanisms

Prostaglandins
Y UenoS Nishio

Abstract

We examined whether beraprost sodium (beraprost), a stable analogue of PGI2, has an anti-inflammatory effect on the permeability barrier through endothelial cells in vivo. The injection of collagen (5 micrograms/head) plus epinephrine (0.6 microgram/head) showed time-dependently the increased Evans blue dye leakage of the lung in mice for 60 min. Beraprost significantly suppressed this leakage dose-dependently (control; 11.26 +/- 1.64 micrograms/lung, beraprost 10 micrograms/kg; 7.49 +/- 1.36 micrograms/lung, 30 micrograms/kg; 5.33 +/- 0.71 micrograms/lung, 100 micrograms/kg; 5.52 +/- 0.79 micrograms/lung). Pulmonary thromboembolism-induced Evans blue dye leakage was also reduced significantly by aspirin (5 mg/kg), but PGE1 (170 micrograms/kg) showed a tendency to potentiate the edematogenic response. One week after the injection of same dosage of collagen plus epinephrine in mice, pulmonary thromboembolism showed the increase of wet-to-dry weight ratio of the lung (normal; 3.84 +/- 0.01, control; 3.96 +/- 0.04) and right ventricular hypertrophy (normal; 28.2 +/- 0.9%, control; 32.3 +/- 0.9%) compared to normal mice. Beraprost significantly suppressed lung edema and hypertrophy dose-dependently, and over 30 micrograms/kg/day of...Continue Reading

References

Apr 1, 1978·Prostaglandins·K KomoriyaR L Magolda
Mar 1, 1979·British Journal of Pharmacology·T J Williams
Jul 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·E G LangelerV W van Hinsbergh
Dec 1, 1986·British Journal of Pharmacology·T AkibaN Toda
Jan 1, 1987·Japanese Journal of Pharmacology·T UmetsuS Nishio
Feb 1, 1981·The Journal of Clinical Investigation·N K Hopkins, R R Gorman
Aug 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R Imai-SasakiT Nakadate
Oct 1, 1993·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M KainohT Nakadate
Jul 1, 1952·British Heart Journal·R M FULTONA M JONES

❮ Previous
Next ❯

Citations

Oct 24, 2009·Journal of Applied Physiology·Anna A BirukovaKonstantin G Birukov
Dec 8, 2009·Microvascular Research·Anna A BirukovaKonstantin G Birukov
Dec 17, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Anna A BirukovaKonstantin G Birukov
Aug 9, 2015·International Immunopharmacology·Amene SaghazadehNima Rezaei
Apr 17, 2013·International Immunopharmacology·Li-da JinLie-Lie Jin
Nov 11, 2011·Angiology·Eleni BousoulaGenovefa D Kolovou
Oct 31, 2017·Tissue Barriers·Pratap Karki, Konstantin G Birukov
Nov 3, 2020·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Daiki HorikamiTakahisa Murata

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.