Anti-inflammatory effects of Forsythia suspensa in dextran sulfate sodium-induced colitis

Journal of Ethnopharmacology
Youn-Hwan HwangJin Yeul Ma

Abstract

Forsythia suspensa Fructus (FS) is used to treat various inflammatory disorders in traditional Oriental medicine, including gastrointestinal diseases, but its therapeutic potential in ulcerative colitis is unclear. Thus, we investigated any potential therapeutic effects of FS against intestinal inflammation and the bioactive constituents in FS. After the induction of colitis using 3% dextran sulfate sodium, FS (100mg/kg/day) was administered orally during the experimental period. We evaluated body weight, bloody diarrhea, colon length, and pro-inflammatory cytokine levels. Subsequently, the bioactive constituents of FS were identified using UPLC/MS/MS. FS significantly decreased the body weight loss, colon length shortening, and tumor necrosis factor-α and interleukin-6 elevations induced by colitis compared with the negative control (P < 0.05). Moreover, FS improved the colitis-induced histopathological damage to the colon, including epithelial necrosis, infiltration of inflammatory cells, ulceration, and submucosal edema. In phytochemical analyses, 7 flavonoids, 9 lignans, 13 phenolics, and 2 triterpenes were identified by comparison with the retention times and mass fragmentations of authentic standards. We demonstrated bene...Continue Reading

Citations

Mar 7, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Tian ZhangTong Zhang
May 23, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Shiying WangJiang Lin
Aug 11, 2019·Nutrients·Youn-Hwan HwangHyunil Ha
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhaoxin ZhangWu Yin
Feb 17, 2021·Drug and Chemical Toxicology·Yinlu LiuBo Zhang

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