Anti-inflammatory effects of millet bran derived-bound polyphenols in LPS-induced HT-29 cell via ROS/miR-149/Akt/NF-κB signaling pathway

Oncotarget
Jiangying ShiZhuoyu Li

Abstract

The pro-inflammatory and anti-inflammatory maladjustment has been acknowledged as one of the chief causations of inflammatory diseases and even cancers. Previous studies showed that plant-derived polyphenolic compounds were the most potent anti-oxidant and anti-inflammatory agents among all natural compounds. The present study indicates that bound polyphenols of inner shell (BPIS) from foxtail millet bran can display anti-inflammatory effects in LPS-induced HT-29 cells and in nude mice. Mechanistically, BPIS restrained the level of various pro-inflammatory cytokines (IL-1β, IL-6, IL-8), and enhanced the expression level of anti-inflammatory cytokine (IL-10) by blocking the nuclear factor-kappaB (NF-κB)-p65 nuclear translocation. Further, we found the elevated miR-149 expression by BPIS-induced ROS accumulation, directly targeted the Akt expression to block NF-κB nuclear translocation. Taken together, these novel findings provide new insights into the development of BPIS as an anti-inflammatory agent via the signaling cascade of ROS/miR-149/Akt/NF-κB axis.

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Citations

Sep 7, 2018·Experimental and Therapeutic Medicine·Jiasheng BaoZhengwen Zhou
Jan 19, 2018·Molecular Medicine Reports·Yuxin BaoGuanghong Xie
Aug 12, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Bjoern TitzManuel C Peitsch
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May 21, 2021·Critical Reviews in Food Science and Nutrition·Huiqin GuoZhuoyu Li
Feb 25, 2020·Journal of Agricultural and Food Chemistry·Zhenyu WangShaoling Lin
Mar 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiaojie ChenQingjiang Pang
Oct 26, 2021·Gut Microbes·Jingpeng YangHe Huang

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Methods Mentioned

BETA
nuclear translocation
ELISA
xenograft
xenografts
PCR
protein extraction
protein
electrophoresis
transfections
Assay

Software Mentioned

DIANA
miRanda
SPSS

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