Anti-inflammatory effects of minocycline are mediated by retinoid signaling

BMC Neuroscience
Vera ClemensJ Hellmann-Regen

Abstract

Minocycline is a lipophilic tetracycline of increasing appeal in neuroscience as it inhibits microglial activation, a mechanism involved in numerous neuropsychiatric disorders. Own data point towards retinoid-mediated effects of minocycline in murine brain and skin, and towards a vicious cycle of neuroinflammation which is driven by microglial activation-induced breakdown of local retinoids such as retinoic acid (RA). We therefore sought to study minocycline's anti-inflammatory effects on human microglial-like monocyte-derived cells in the context of retinoid signaling. As hypothesized, minocycline exposure resulted in a substantial increase of RA levels in the human monocytic cell line THP-1. While pro-inflammatory stimulation with lipopolysaccharides resulted in increased tryptophane-degrading indoleamine-2,3-dioxygenase IDO-expression and TNF-α levels in primary human monocyte-derived microglial-like cells, this effect was attenuated by minocycline only in the presence of retinoids. The anti-inflammatory effects of minocycline on TNF-α expression were completely abolished by a pharmacological blockage of retinoic acid receptors (RARs) using BMS-493 and unaffected by selectively blocking retinoid-X-receptors using UVI-3003. O...Continue Reading

References

Jan 1, 1992·Neuroscience·L J LawsonS Gordon
May 16, 2001·Archives of General Psychiatry·A ReichenbergT Pollmächer
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T M Tikka, J E Koistinaho
Jan 29, 2005·American Journal of Clinical Dermatology·Deborah I Friedman
Jul 28, 2006·Journal of Psychiatric Research·Sinead M O'BrienTimothy G Dinan
Jul 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tae Y YuneTae H Oh
Aug 21, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Douglas Bremner, Peter McCaffery
Oct 16, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Miguel Molina-HernándezM Teresa Jaramillo-Jaimes
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Jun 17, 2008·Progress in Neurobiology·Sabien van NeervenJörg Mey
Jul 22, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Miguel Molina-HernándezM Teresa Jaramillo-Jaimes
Oct 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bita MaghsoodiLu Chen
Jan 20, 2009·Biological Psychiatry·Andrew H MillerCharles L Raison
Sep 29, 2009·Perspectives in Psychiatric Care·Jessica M GillGayle Page
Aug 17, 2010·Journal of Neuroimmunology·Morgana M M VieiraCleonice A M Bento
Sep 10, 2010·Journal of Neuroimmunology·Sabien van NeervenJörg Mey
Apr 30, 2011·Physiological Reviews·Helmut KettenmannAlexei Verkhratsky
Feb 22, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tsuyoshi MiyaokaJun Horiguchi
Apr 11, 2012·CNS Drugs·Olivia M DeanMichael Berk
Jun 9, 2012·Nature Reviews. Neuroscience·Robert SchwarczHui-Qiu Wu
Jan 10, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sophie ErhardtLena Brundin
Feb 7, 2013·Journal of Neuroimmunology·Julian Hellmann-RegenKaren Gertz
Apr 10, 2014·Nature Reviews. Neuroscience·Marco Prinz, Josef Priller
Dec 10, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Yechiel LevkovitzHagit Cohen
Mar 27, 2015·Experimental Dermatology·Francesca RegenJulian Hellmann-Regen
May 20, 2015·Journal of Neural Transmission·Julian Hellmann-RegenGolo Kronenberg
May 23, 2015·Developmental Neuroscience·Tomoyuki Takano
Jun 6, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·F RegenJ Hellmann-Regen
Oct 13, 2015·British Journal of Pharmacology·L E LaskarisC Pantelis

❮ Previous
Next ❯

Citations

Jul 24, 2020·Molecular Neurobiology·Leszek Rudzki, Michael Maes
Oct 3, 2019·Expert Review of Clinical Immunology·Rebecca L YanovskyA Razzaque Ahmed
May 31, 2020·Psychopharmacology·Eric Murillo-RodríguezPablo Torterolo
Oct 6, 2020·Journal of Oncology·Amir R AfshariAmirhossein Sahebkar
Jan 26, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Laura Donaldson, Edward Margolin

❮ Previous
Next ❯

Methods Mentioned

BETA
FCS
PCR

Clinical Trials Mentioned

NCT02456948

Software Mentioned

GraphPad Prism

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here