Anti-inflammatory effects of once daily low dose inhaled ciclesonide in mild to moderate asthmatic patients

Allergy
A M WilsonPaul M O'Byrne

Abstract

Ciclesonide exhibits clinical efficacy at 160 microg (ex-actuator) once daily but the anti-inflammatory effects at this dose are not known. We wished to know whether 4 weeks therapy with ciclesonide pMDI 160 microg once daily in the morning exhibited significant anti-inflammatory effects. Seventeen patients with mild persistent asthma (FEV(1) 3.35 l) were recruited into a double-blind placebo-controlled randomized crossover study. Measurements were made after ciclesonide and placebo treatment as well as after run-in and washout periods, for adenosine monophosphate (AMP) bronchial challenge (primary variable), exhaled nitric oxide (NO) and induced sputum (in a subgroup). The mean (SEM) AMP bronchial challenge PC(20) following ciclesonide (140 (63) mg/ml) was significantly (P < 0.001) increased compared with placebo (17 (8) mg/ml), run-in (13 (5) mg/ml) and washout (9 (3) mg/ml) periods. This amounted to an eightfold (CI: 5.3-12.0) for ciclesonide vs placebo. Likewise, there were significant improvements in exhaled NO levels and a significant reduction in induced sputum eosinophil cell counts. We have shown that inhaled ciclesonide given at 160 microg once daily in the morning exhibits significant anti-inflammatory effects that a...Continue Reading

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Citations

Jan 1, 2009·Journal of Asthma and Allergy·Timothy J Schaffner, David P Skoner
Apr 21, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Luis MansoJoaquín Sastre
Apr 9, 2009·Expert Opinion on Pharmacotherapy·Sabina Antonela Antoniu, Carmen Monica Pop
Apr 20, 2010·COPD·Nesreen M HassanParameswaran Nair
Apr 25, 2006·Allergy·M Humbert
Apr 7, 2007·Journal of Clinical Pharmacology·Hartmut Derendorf
Dec 26, 2009·Allergology International : Official Journal of the Japanese Society of Allergology·Makoto Hoshino
Apr 22, 2008·The Cochrane Database of Systematic Reviews·P ManningT J Lasserson
Sep 26, 2019·The Cochrane Database of Systematic Reviews·Sadia JanjuaChristopher J Cates
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Aug 7, 2008·Drugs·Emma D Deeks, Caroline M Perry
Dec 16, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Robert S ZeigerWansu Chen

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