Anti-inflammatory effects of (Z)-ligustilide through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways

Archives of Pharmacal Research
Ji Won ChungYeong Shik Kim

Abstract

The roots of Angelica tenuissima have been commonly used for the treatment of cardiovascular diseases and menstrual discomfort in Asian countries, such as China and Korea. The primary volatile flavor components are essential oil ingredients, phthalide lactones. In this study, (Z)-ligustilide was tested for its anti-inflammatory activities in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. We found that (Z)-ligustilide strongly inhibitis the induction of LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at both the mRNA and protein levels in a dose-dependent manner. The transcriptional activity of nuclear factor kappa B (NF-B) was also down-regulated in a concentration-dependent manner. Further study revealed that (Z)-ligustilide inhibited the phosphorylation and subsequent degradation of IBα, an inhibitor protein of NF-B. In addition, (Z)-ligustilide inhibited the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK) and c-Jun NH(2)-terminal kinase (JNK) in a dose-dependent manner. Taken together, these data suggest that (Z)-ligustilide can exert its antiinflammatory effects by regulating the NF-B and MAPK signal pathways.

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Citations

Nov 2, 2013·International Journal of Molecular Sciences·Yu-Jin HwangKyung-A Hwang
Oct 16, 2015·Phytotherapy Research : PTR·Takuhiro UtoYukihiro Shoyama
Aug 2, 2015·Journal of Ethnopharmacology·Yan LiYonghua Wang
Sep 18, 2015·Frontiers in Plant Science·Ibrahim JantanSyed Nasir Abbas Bukhari
Jan 28, 2015·European Journal of Pharmacology·Mayela Del-ÁngelGuillermo Delgado
Oct 8, 2013·Pharmaceutical Biology·Krutzkaya Juárez-ReyesRachel Mata
Apr 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenxia GongGuanhua Du
Jul 12, 2016·Journal of Natural Products·Lai-Bin ZhangJun-Wei Liu
Mar 7, 2020·Phytotherapy Research : PTR·Qingxuan XieXiaofang Li
Sep 25, 2018·Frontiers in Pharmacology·Ali AttiqWaqas Ahmad
Dec 4, 2020·Biological & Pharmaceutical Bulletin·Febby Nurdiya NingsihMikio Nishizawa
Sep 3, 2020·Journal of Ethnopharmacology·Ruifang YuanMing Yang
Feb 1, 2020·Current Medicinal Chemistry·Amir R AfshariAmirhossein Sahebkar

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