Anti-inflammatory Labdane Diterpenoids from Leonurus macranthus

Journal of Natural Products
Zheng HuangJun Li

Abstract

Twenty new polyoxygenated labdane diterpenoids (1-20) were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The absolute configurations of macranthin A (1) and 6-O-deacetylmacranthin A (2) were determined by single-crystal X-ray crystallographic analysis and a modified Mosher's method, respectively. Compounds 1-9, 12, 14, and 19 showed inhibition of nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells with IC50 values of 10.0-63.7 μM.

References

Dec 25, 2007·Acta Crystallographica. Section A, Foundations of Crystallography·George M Sheldrick
Feb 1, 2008·Journal of Applied Crystallography·Rob W W HooftAnthony L Spek
Jul 29, 2010·Planta medica·María L KennedyIgnacio A Jiménez
Mar 8, 2011·Journal of Natural Products·Hankui WuJordan K Zjawiony
Apr 9, 2011·The American Journal of Chinese Medicine·Zhi-Ye YangZhi Chao
Oct 19, 2011·Clinical and Experimental Pharmacology & Physiology·Xin H LiuYi Z Zhu
Mar 27, 2012·Phytochemistry·Hankui WuJordan K Zjawiony
Apr 6, 2012·Journal of Natural Products·Jun LiJordan K Zjawiony
Oct 9, 2012·Phytotherapy Research : PTR·Katarzyna WojtyniakIrena Matławska
May 3, 2013·Journal of Natural Products·Ki Hyun KimKang Ro Lee
Apr 9, 2014·Journal of Natural Products·Hui LiPeng-Fei Tu
Aug 8, 2014·Journal of Natural Products·Chung Sub KimKang Ro Lee
Sep 24, 2014·Journal of Natural Products·Man-Man LiPeng-Fei Tu

❮ Previous
Next ❯

Citations

Dec 5, 2015·Organic Letters·Liang XiongCheng Peng
Mar 30, 2016·Journal of Natural Products·Quírico A CastilloEvelyn A Germosén
Jul 21, 2016·Phytochemical Analysis : PCA·Nilufar Z MamadalievaSatyajit D Sarker
Nov 11, 2016·Natural Product Research·Yue-Ting LiJun Li
Mar 21, 2018·Natural Product Research·Yi RenJun Li
Jul 29, 2016·Natural Product Reports·James R Hanson
Aug 22, 2017·Frontiers in Bioengineering and Biotechnology·Isabel MartinsCristina Silva Pereira
Jul 1, 2019·European Journal of Medicinal Chemistry·Navneet KishoreAkhilesh Kumar Verma
Jul 20, 2018·Journal of Natural Products·Ruifei ZhangXingyun Chai
Sep 11, 2019·Journal of Natural Products·Hang-Ying LiKun Gao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.