Anti-inflammatory Lathyrane Diterpenoids from Euphorbia lathyris

Journal of Natural Products
Cui-Yun ZhangLixia Chen

Abstract

Six new lathyrane diterpenoids (1-6) and 10 known analogues (7-16), were separated from the seeds of Euphorbia lathyris. The absolute configuration of 1 was determined by X-ray crystallography, and the C-2' configuration of 5 was elucidated by comparing experimental and calculated ECD data. These compounds were studied for their inhibition against nitric oxide (NO) generation induced by lipopolysaccharide in RAW264.7 macrophage cells. Compounds 1-3, 7, 9, 11, 13, 14, and 16 displayed inhibitory effects on NO production, with IC50 values of 2.6-26.0 μM. The new compound 1 (IC50 3.0 ± 1.1 μM), with no obvious cytotoxicity, was selected for further experiments. The production of cytokines such as IL-6 and IL-1β, as well as the protein expression of iNOS, NF-κB, and phosphorylated IκBα, was reduced by 1 dose-dependently. These results suggested that lathyrane diterpenoids may be used as potential anti-inflammatory agents and are worth being further researched.

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Citations

Nov 23, 2019·Chemistry & Biodiversity·Jian-Chun LiHong-Mei Li
Jul 25, 2019·Frontiers in Plant Science·Madeleine ErnstNina Rønsted
Oct 28, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·An ZhuQi Wang
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Douglas KemboiVuyelwa Jacqueline Tembu
Aug 28, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Hui-Nan WangYing-Zi Wang
Oct 20, 2021·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Mingcheng WangDechun Jiang

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