Anti-inflammatory potential of alginic acid from Sargassum horneri against urban aerosol-induced inflammatory responses in keratinocytes and macrophages

Ecotoxicology and Environmental Safety
Ilekkuttige Priyan Shanura FernandoWonWoo Lee

Abstract

The airborne particulate pollutants originating in the deserts of Mongolia and China which becomes contaminated with industrial effluents and traffic emissions while moving with the wind currents towards East Asia has recently become a serious environmental and health issue in the region. They cause asthma, collateral lung tissue damage, oxidative stress, allergic reactions, and inflammation. The current study was undertaken to evaluate the protective effects of alginate extracted from the invasive alga Sargassum horneri (SHA) against fine dust collected from Beijing, China (Chinese fine dust; CFD). It was found that CFD induces inflammation in HaCaT keratinocytes and inhibits macrophage activation. All of the particulate matter (PM) comprising CFD was < PM13 majority being < PM2.5 which is defined for mineral elements and polycyclic aromatic hydrocarbons. SHA attenuated PGE2 levels in CFD-induced HaCaT keratinocytes. The IC50 for SHA was 36.63 ± 4.11 µg mL-l. SHA also reduced the levels of COX-2, IL-6, and TNF-α, and inhibited certain key molecular mediators of the NF-κB and MAPK pathways in keratinocytes. SHA substantially reduced the levels of CFD-derived metal ions like Pb2+ and Ca2+ in keratinocytes attributable to its met...Continue Reading

Citations

Sep 11, 2018·Critical Reviews in Biotechnology·Ilekuttige Priyan Shanura FernandoYou-Jin Jeon
Jun 25, 2020·Marine Drugs·Krishnapriya ThiyagarasaiyarYoon-Yen Yow
Jul 28, 2020·Particle and Fibre Toxicology·Irini M DijkhoffBarbara Rothen-Rutishauser
Jun 12, 2020·Food Science and Biotechnology·Ju Hee LeeHyun Jung Kim
Dec 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thilina U JayawardenaYou-Jin Jeon
Nov 22, 2020·International Journal of Biological Macromolecules·Ilekuttige Priyan Shanura FernandoGinnae Ahn
Jul 1, 2020·International Journal of Biological Macromolecules·Ilekuttige Priyan Shanura FernandoGinnae Ahn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Kil-Nam KimDaekyung Kim
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Dong-Joo KwonJinseu Park
© 2022 Meta ULC. All rights reserved