Anti-inflammatory potential of chia seeds oil and mucilage against adjuvant-induced arthritis in obese and non-obese rats.

Journal of Basic and Clinical Physiology and Pharmacology
Doha A MohamedKarem Fouda

Abstract

Background Natural anti-inflammatory nutraceuticals may be useful in suppressing the incessant aggravation of rheumatoid arthritis. Chia seeds as a natural source of antioxidants help prevent several oxidative stress-mediated diseases. The current study was focused on arthritis combined with obesity and evaluated the validation of oil and mucilage extracted from chia seeds as anti-inflammatory nutraceuticals in obese and non-obese adjuvant arthritic rat model. Methods Chia seeds oil was extracted by pressing method, whereas the mucilage was extracted using water (50 °C for 30 min). Oil and freeze-dried mucilage were tested for their anti-inflammatory effects using 48 male Sprague-Dawley rats. Obesity was developed in rats after 8 weeks of feeding on high-fat high-sucrose diet; on the first day of the ninth week, chia seeds oil and mucilage were administrated for 21 days, and arthritis was induced either in obese or non-obese rats via the injection with Freund's complete adjuvant. Swelling of the paw was then measured. Plasma tumor necrosis factor (TNF-α), lipid profile, liver and kidney functions, serum lipid peroxidation, and erythrocyte catalase activity were determined. Results Results emphasized that arthritis with obesity ...Continue Reading

References

May 1, 1992·The Journal of Pharmacy and Pharmacology·G B SinghS K Banerjee
Jan 1, 1984·Methods in Enzymology·H Aebi
Sep 1, 1960·Clinica Chimica Acta; International Journal of Clinical Chemistry·D WATSON
Mar 1, 1960·Journal of Clinical Pathology·J K FAWCETT, J E SCOTT
Mar 8, 2008·Arthritis Research & Therapy·Antonio NaranjoUNKNOWN QUEST-RA Group
Oct 21, 2010·Rheumatology·Antonios Stavropoulos-KalinoglouGeorge D Kitas
Feb 2, 2013·Canadian Journal of Physiology and Pharmacology·Sean BryanNeelam Khaper
Dec 17, 2016·Food Chemistry·Bárbara Pereira da SilvaHelena Maria Pinheiro-Sant'Ana
Mar 28, 2017·Nutrients·Mirjana VeselinovicVladimir Jakovljevic
Oct 1, 2015·Food Research International·Rafaela da Silva MarineliMário Roberto Maróstica
May 12, 2017·Food Chemistry·Sheila Cristina Oliveira-AlvesMaria Rosário Bronze
Oct 25, 2017·Journal of Advanced Research·Hong Sheng ChengKhalid Abdul Kadir
Jun 26, 2018·Food Science and Biotechnology·Grzegorz DąbrowskiSylwester Czaplicki
Sep 29, 2018·International Journal of Molecular Sciences·Andrea Picchianti-DiamantiValerio Pazienza
Dec 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yingbin ShenXun Song
Jun 21, 2019·Food & Function·Bárbara Pereira da SilvaHércia Stampini Duarte Martino

❮ Previous
Next ❯

Citations

Sep 16, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mariangela RondanelliChiara Rigon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.