Anti-inflammatory properties of a wound dressing combination of zinc oxide and turmeric extract

Veterinary World
Asti MeizariniAstari Puteri

Abstract

The aim of this study was to determine the effect of a wound dressing consisting of a zinc oxide with turmeric extract combination as an anti-inflammatory on the healing process through the expression of MAC387 and cyclooxygenase-2 (COX-2). Forty Wistar rats were divided into four control and four treatment groups (n=5). On day 1, a 6 mm×6 mm square of skin in the area of the vertebralis thoracis was excised from all subjects. The wound was then dressed with a combination of zinc oxide and turmeric extract for the treatment groups, while the control groups were left undressed. Both the control and treatment groups were then sequentially sacrificed on days 3, 5, 7, and 14 to obtain subepithelial excision samples. These samples subsequently underwent immunohistochemistry examination through the expression of MAC387 and COX-2 to ascertain the anti-inflammatory reaction to the wound healing process. The highest expression of MAC387 was found in the treatment group to which a dressing of zinc oxide with turmeric extract had been applied on the day 5 before slowly reducing on days 7 and 14. MAC387 peaked in the undressed control group on day 14. The COX-2 expression results in control groups showed their higher expression on day 3, i...Continue Reading

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Citations

Aug 19, 2020·Drug Development and Industrial Pharmacy·Diana G SamiHassan M E Azzazy
Dec 15, 2020·European Journal of Medicinal Chemistry·Maryam Sadat Hosseini-ZareChelliah Selvam
Aug 13, 2021·Journal of Indian Prosthodontic Society·Jennifer WidjajaAsti Meizarini

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