PMID: 9661288Jul 14, 1998Paper

Anti-inflammatory properties of diclofenac transition metalloelement complexes

Journal of Inorganic Biochemistry
M KonstandinidouM Demertzis

Abstract

As part of our research into understanding drug-metalloelement interactions, we have prepared complexes of Cu(II), Co(II), Ni(II), Mn(II), Fe(II), Fe(III), and Pd(II) with Diclofenac, in order to investigate their anti-inflammatory activity. Their inhibitory effects on rat or mouse paw edema induced by Carrageenan, Con-A, Nystatin, and Baker's yeast were compared with those of Diclofenac. Furthermore, the action of Diclofenac's metalloelement complexes on phagocytosis of yeast by rat peritoneal cells, as well as the capacity of some of the metalloelement complexes to inhibit lipid peroxidation of liver microsomal membranes was also investigated. These complexes exhibited a strong inhibitory effect on Carrageenan-, ConA-, and Nystatin-induced edemas (35-80% inhibition) comparable to the inhibition caused by Diclofenac (61-76% inhibition). Furthermore, complexes with Co(II), Ni(II), Pd(II), and Mn(II) were found to have an anti-inflammatory profile (35-50% inhibition) superior to diclofenac (17% inhibition) when inhibiting inflammations due to Baker's yeast, the mechanism of which involves mainly the activation of lipoxygenase and/or complement system. Complexes of Ni(II) and Pd(II), which showed significant inhibition of induced...Continue Reading

References

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Citations

Apr 12, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·A FiniG Fazio
Oct 4, 2005·Journal of Pharmaceutical Sciences·Adamo FiniJosefa Alvarez-Fuentes
Feb 11, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·K H Kumar NaikAvinash Prakasha
Nov 16, 2018·Journal of Biochemical and Molecular Toxicology·Akif Evren ParlakMustafa Karatepe
Jun 7, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Jie FengJingyan Zhang

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