Mar 5, 2020

Anti-inflammatory role of GM1 and modulatory effects of gangliosides on microglia functions

bioRxiv
Danny GalleguillosSimonetta Sipione

Abstract

Gangliosides are sialic acid-containing glycosphingolipids highly enriched in the brain. Located mainly at the plasma membrane, gangliosides play important roles in signaling and cell-to-cell communication. Lack of gangliosides causes severe early onset neurodegenerative disorders, while more subtle deficits have been reported in Parkinson disease and in Huntington disease, two misfolded protein diseases with a neuroinflammatory component. On the other hand, administration of ganglioside GM1 provides neuroprotection in both diseases and in several other models of neuronal insult. While most studies have focused on the role of endogenous gangliosides and the effects of exogenously administered GM1 in neurons, their contribution to microglia functions that are affected in neurodegenerative conditions is largely unexplored. Microglia are the immune cells of the brain and play important homeostatic functions in health and disease. In this study, we show that administration of exogenous GM1 exerts a potent anti-inflammatory effect on microglia activated with LPS, IL-1beta or upon phagocytosis of latex beads. These effects are partially reproduced by L-t-PDMP, a compound that stimulates the activity of the ganglioside biosynthetic pa...Continue Reading

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Mentioned in this Paper

Transcription, Genetic
BDNF
Administration Procedure
Brain
Body Structure
Immune Effector Cell
Ganglioside Biosynthesis Pathway
Neurodegenerative Disorders
Plasma Membrane
Ganglioside GM1

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