Anti-inflammatory role of the isoflavone diadzein in lipopolysaccharide-stimulated microglia: implications for Parkinson's disease.

Neurotoxicity Research
Shankar J ChintaJulie K Andersen

Abstract

Microglial activation and subsequent release of toxic pro-inflammatory factors are believed to play an important role in neuronal cell death associated with Parkinson's disease (PD). Compounds that inhibit microglia activation and suppress pro-inflammatory factor release have been reported to have neuroprotective effects in animal models of PD. In this study, we tested whether diadzein, a natural isoflavone found in soybean, attenuated lipopolysaccharide (LPS)-induced release of inflammatory mediators in BV-2, a murine microglial cell line. Diadzein pretreatment was found to significantly suppress the production of the pro-inflammatory factors nitric oxide and IL-6 as well as their mRNA expression in conjunction with reductions in ROS production, p38 MAPK phosphorylation, and NF-κB activation. Furthermore, transfer of conditioned media (CM) from BV-2 cells pretreated with diadzein resulted in a significantly reduction in dopaminergic neurotoxicity compared with CM from microglia stimulated with LPS alone. Together, our results suggest that diadzein's neuroprotective properties may be due to its ability to dampen induction of microglial activation and the subsequent release of soluble pro-inflammatory factors. This appears to be...Continue Reading

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Citations

Feb 24, 2016·Oxidative Medicine and Cellular Longevity·Lucio G CostaClaudia Pellacani
Jan 30, 2015·Neurotoxicity Research·Juan Segura-Aguilar, Richard M Kostrzewa
Jun 15, 2016·Nutrients·Jie YuDaiwen Chen
Nov 17, 2015·Current Opinion in Pharmacology·Katherine E Olson, Howard E Gendelman
Mar 30, 2018·Nutritional Neuroscience·Juen-Haur HwangYin-Ching Chan
Feb 8, 2018·Journal of Medicinal Food·Un Ju Jung, Sang Ryong Kim
May 20, 2016·Endocrine Reviews·Alessandro VillaAdriana Maggi
Jan 31, 2020·Journal of Cellular and Molecular Medicine·Tian HuShi-Jie Zhang
Oct 17, 2019·Nanoscale Research Letters·Qiao WangYong Chen
Jul 1, 2020·The Chinese Journal of Physiology·Thuy-Lan Thi VoTuzz-Ying Song
Apr 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ghulam HussainTao Sun
May 26, 2018·Nutrition Reviews·Anthony F Juritsch, Régis Moreau
Apr 25, 2018·Journal of Radiation Research·Aydemir KaleÇagatay Büyükuysal
May 6, 2021·International Journal of Molecular Sciences·Lalita SubediSun-Yeou Kim

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