Anti-inflammatory Strategies to Prevent Diabetic Cardiovascular Disease

Clinical Pharmacology and Therapeutics
I Jialal, S Devaraj

Abstract

Diabetes is a proinflammatory state and inflammation is crucial in the genesis of vascular complications. While there are many anti-inflammatory strategies, most of which have been shown to reduce inflammation in diabetes, there is sparse data on reduction in cardiovascular events (CVEs). To date, the only anti-inflammatory strategies that have been shown to reduce CVE in diabetes include statins, angiotensin receptor blockers, metformin, and pioglitazone. We also discuss the role of novel emerging therapies.

References

Mar 6, 2010·Expert Review of Endocrinology & Metabolism·Sridevi DevarajIshwarlal Jialal
Jan 31, 2012·Current Pharmaceutical Design·D Di RaimondoA Pinto
Apr 30, 2013·Current Diabetes Reports·Hanford YauKenneth Cusi
Jul 3, 2013·Annals of Internal Medicine·Allison B GoldfineUNKNOWN Targeting Inflammation Using Salsalate in Type 2 Diabetes Study Team
Nov 21, 2013·Diabetes Care·Joshua I BarzilayUNKNOWN TINSAL-T2D Research Consortium
Jan 7, 2014·Current Diabetes Reports·Sandeep Dhindsa, Ishwarlal Jialal
May 24, 2014·Nature Reviews. Drug Discovery·Marc Y Donath
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Citations

May 28, 2015·Clinical Pharmacology and Therapeutics·S G Terra, J Vincent
Feb 13, 2018·Journal of Diabetes Research·Roma PahwaSridevi Devaraj
Aug 16, 2019·Clinical Cardiology·Zi-Heng ZhengSu-Hua Wu
Jan 28, 2016·American Journal of Physiology. Endocrinology and Metabolism·Ana BurgeiroEugenia Carvalho
Apr 20, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Hee Sue ParkHyun Kyung Kim
Dec 1, 2017·Therapeutic Advances in Cardiovascular Disease·Ishwarlal Jialal, Naval K Vikram

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