Anti-Inflammatory Triterpenoids from the Caulophyllum robustum Maximin LPS-Stimulated RAW264.7 Cells

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Bin-Hua QinHai-Yan Han

Abstract

Caulophyllum robustum Maxim is widely distributed in China and used as a traditional herbal medicine to induce childbirth, ease the pain of labor, rectify delayed or irregular menstruation, alleviate heavy bleeding and pain during menstruation, and treat external injuries and irregular menses. According to our detailed chemical investigation, three new triterpene derivatives (1⁻3), together with seven known compounds, were isolated from the root and rhizome of C. robustum Maxim. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analysis and physio-chemical methods. They were identified as (1) 23-hydroxy-3,19-dioxo-olean-12-en-28-oic-acid; (2) 23-hydroxy-3,11-dioxo-olean-12-en-28-oic acid; and (3) 16α,23-dihydroxy-3-oxo-olean-12-en-28-oic acid. Compounds (1⁻10) inhibited the LPS-activated NO production in RAW264.7 cells. Furthermore, the anti-inflammatory characteristics of these compounds were confirmed on the basis of decreases in iNOS and NF-κB protein expression in RAW264.7 cells.

References

Aug 30, 2011·Journal of Natural Products·Tran H QuangYoung H Kim
May 31, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Yong-Gang XiaHai-Xue Kuang
Aug 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jin-Pyo AnWon Keun Oh
Sep 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seulah LeeKi Hyun Kim
Oct 13, 2017·European Journal of Medicinal Chemistry·Diego Rodríguez-HernándezRené Csuk

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Citations

Apr 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guodong ZhangZheng Li

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Methods Mentioned

BETA
NMR
electrophoresis

Software Mentioned

GraphPad Prism
GraphPad

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