PMID: 9168846Jan 1, 1997Paper

Anti-interleukin-4 inhibits immunoglobulin E production in a murine model of atopic asthma

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
C Y ZhouR G Townley

Abstract

Immunoglobulin E (IgE) plays an important role in allergy, acting as an initiating factor and being involved in its persistence and exacerbations. As interleukin-4 (IL-4) is critical in IgE synthesis, we propose that treatment of mice with monoclonal anti-IL-4 (11B11) prior to active sensitization with ovalbumin will inhibit IgE synthesis, therefore arresting the allergic process at an early stage. Mice treated with 11B11 and sensitized with saline or ovalbumin had significantly less serum IgE than their respective control groups which were treated with saline (p < 0.05). This study suggests that anti-IL-4 may be a prophylactic agent in asthma and allergic disease.

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Citations

Jul 1, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I C CrockerR G Townley
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Nov 6, 2020·Inflammopharmacology·Madhur D ShastriPhilip M Hansbro

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