PMID: 8972745Dec 1, 1996Paper

Anti-interleukin-6 autoantibodies in plasma are associated with an increased frequency of infections and increased mortality of patients with alcoholic cirrhosis

Scandinavian Journal of Immunology
C HomannP Garred

Abstract

Altered cytokine metabolism has been implicated in the pathogenesis of alcoholic liver disease. Recently, autoantibodies to cytokines have been proposed to act as modifiers of cytokine functions. In this study plasma levels of anti-interleukin-1 alpha (IL-1 alpha autoantibodies and anti-IL-6 autoantibodies were determined by RIAs in 96 patients with alcoholic cirrhosis and in 16 healthy individuals. After 19 months (median) the prognostic significance of the cytokine autoantibodies was investigated using univariate analysis (Log-rank test) and multivariate regression analysis (Cox model). The seroprevalences of anti-IL-1 alpha autoantibodies and anti-IL-6 autoantibodies (42 and 18%, respectively) in the patients were not different from healthy individuals and did not relate to severity of liver disease. The presence of anti-IL-1 alpha autoantibodies was of no prognostic significance. Independent of severity of liver disease, patients with anti-IL-6 autoantibodies in plasma had a higher risk of acquiring infections and higher risk of death (P < 0.02) compared to patients without anti-IL-6 autoantibodies. The authors concluded that anti-IL-6 autoantibodies are associated with increased mortality when present in the plasma of pati...Continue Reading

Citations

Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·W Y ParkT R Martin
Feb 7, 2014·Annual Review of Immunology·Sarah K Browne
Apr 27, 2010·Cytokine & Growth Factor Reviews·Masato WatanabeKoh Nakata
Feb 14, 2009·Cytokine & Growth Factor Reviews·Carina de Lemos RieperMorten Bagge Hansen
Jan 31, 2015·Autoimmunity Reviews·Thierry VincentJean François Eliaou
Apr 1, 2000·Addiction Biology·I G McFarlane
Sep 16, 2004·European Journal of Immunology·Pia GalleMorten B Hansen
Sep 3, 2010·Nature Reviews. Drug Discovery·Manfred KopfBenjamin J Marsland
Mar 19, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Kit P LundHelle Bruunsgaard
Jun 6, 2014·Expert Review of Clinical Immunology·Anthony Meager, Meenu Wadhwa
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne PuelJean-Laurent Casanova
Jan 15, 2016·Antibodies·Vijaya KnightMichael D O'Sullivan
Mar 18, 2020·Genes & Diseases·Ankita SinghAmit Rawat

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