PMID: 9450141Feb 5, 1998Paper

Anti-interleukin (IL)-4 and -IL-5 antibodies downregulate IgE and eosinophilia in mice exposed to Aspergillus antigens

Allergy
V P KurupR L Coffman

Abstract

The effect of multiple divided doses compared with single-dose injections of antibodies to murine interleukin (IL)-4 and IL-5 in their respective downregulation of IgE and eosinophilia developing in a model of allergic aspergillosis is investigated. BALB/c mice were exposed to Aspergillus fumigatus antigens (Af) before and along with anticytokine antibodies. The kinetics of blood eosinophils, eosinophil peroxidase (EPO) in bone-marrow cells, serum levels of IgE and Af-specific antibodies, Af-induced cytokine production and mRNA, and lung histology were studied. The results indicate that only multiple anti-IL-5 antibodies were effective in maintaining baseline levels of blood eosinophils. Multiple anti-IL-4 antibodies also downregulated eosinophils in the bone marrow, lung, and peripheral blood, although to a lesser extent than in anti-IL-5 antibody-injected mice. Significant correlation between the EPO activity and the eosinophil numbers in anticytokine antibody-treated mice was observed. The different anti-IL-4 antibody treatments downregulated IgE to the same extent. We conclude that multiple divided doses of anti-IL-5 antibodies are required to sustain normal eosinophil levels in murine allergic aspergillosis. This informati...Continue Reading

References

May 1, 1992·Infection and Immunity·P S MuraliV P Kurup
Jan 1, 1992·Clinical Immunology and Immunopathology·P F Weller
Jan 1, 1991·Research in Immunology·R M LocksleyM D Sadick
Nov 1, 1991·Science·R KühnW Müller
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A SherA W Cheever
Jan 1, 1990·Annals of the New York Academy of Sciences·A K Harris
Feb 1, 1989·Immunology Today·F Y Liew
Jan 1, 1988·The Journal of Experimental Medicine·C M SnapperW E Paul
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F D FinkelmanW E Paul
Nov 1, 1994·Journal of Leukocyte Biology·V P KurupR L Coffman
Sep 1, 1994·International Archives of Allergy and Immunology·T T KungA S Watnick
Jan 1, 1994·International Archives of Allergy and Immunology·V P KurupJ N Fink
Mar 1, 1993·Journal of Leukocyte Biology·P S MuraliV P Kurup

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Citations

Aug 28, 1998·Research in Immunology·V P KurupP S Murali
Oct 18, 2003·Cytokine & Growth Factor Reviews·Jane M SchuhCory M Hogaboam
May 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K G TournoyR A Pauwels
Feb 15, 2002·Veterinary Dermatology·C Noli, A Miolo
Oct 22, 2005·Infection and Immunity·Amariliz RiveraEric G Pamer
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·L C BorishL Garrison
May 3, 2011·PloS One·Steven P TempletonDonald H Beezhold
Jan 9, 2010·Medical Mycology·Steven P TempletonDetlef Schmechel
Aug 21, 2013·The Journal of Allergy and Clinical Immunology·Sonia Schuepbach-MallepellOlivier Gaide
Feb 17, 2010·Immune Network·Neelkamal ChaudharyPuranam Usha Sarma
Feb 7, 2001·Biochemical Pharmacology·W S Wong, D S Koh
Mar 10, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·V P KurupK J Kelly
Mar 17, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·V P KurupJ N Fink
Nov 14, 2016·Medical Mycology·Takahiro Takazono, Donald C Sheppard
Jun 23, 2005·Allergy·I Tillie-Leblond, A-B Tonnel
Feb 29, 2020·European Journal of Immunology·Axel DietschmannDavid Voehringer
Apr 9, 1999·Clinical Microbiology Reviews·J P Latgé

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