Anti-invasive activity of bovine lactoferrin towards group A streptococci

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Maria AjelloPiera Valenti

Abstract

Group A streptococci (GAS) are able to invade cultured epithelial and endothelial cells without evidence of intracellular replication. GAS, like other facultative intracellular bacterial pathogens, evolved such ability to enter and to survive within host cells avoiding the host defences, and bacterial intracellular survival could explain the recurrence of infections. We report here that 1 mg bovine lactoferrin (bLf)/mL significantly hindered the in vitro invasion of cultured epithelial cells by GAS isolated from patients suffering from pharyngitis and completely inhibited the invasiveness of GAS pretreated with subinhibiting concentrations of erythromycin or ampicillin. One milligram of bLf per millilitre was also able to increase the number of epithelial cells undergoing apoptosis following GAS invasion, although the number of intracellular GAS in the presence of bLf decreased by about 10-fold. The ability of bLf to decrease GAS invasion was confirmed by an in vivo trial carried out on 12 children suffering from pharyngitis and already scheduled for tonsillectomy. In tonsil specimens from children treated for 15 days before tonsillectomy with both oral erythromycin (500 mg t.i.d. (three times daily)) and bLf gargles (100 mg t....Continue Reading

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Citations

Jul 19, 2012·World Journal of Microbiology & Biotechnology·Dorien S CorayJacqueline I Keenan
Jan 30, 2008·Infection and Immunity·Simon R Clarke, Simon J Foster
May 2, 2003·Expert Opinion on Investigational Drugs·Eugene D Weinberg
Feb 26, 2003·Journal of Medical Virology·Assunta Maria Di BiaseFabiana Superti
May 3, 2006·Molecular and Cellular Endocrinology·Andrew GreyJill Cornish
Oct 21, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Grzegorz MajkaMagdalena Strus
Jan 18, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Rosa SessaPiera Valenti
Sep 16, 2017·International Journal of Molecular Sciences·Luigi RosaPiera Valenti
Mar 9, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Luigi RosaPiera Valenti
Feb 21, 2019·Human & Experimental Toxicology·I RadicS J Hudomal
Apr 21, 2004·Journal of Medical Microbiology·Assunta Maria Di BiaseFabiana Superti
Jan 12, 2008·Journal of the American College of Nutrition·Geoffrey W Krissansen
Jun 29, 2004·Journal of Clinical Gastroenterology·Piera ValentiLucilla Seganti

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