PMID: 2511567Oct 1, 1989Paper

Anti-ischaemic effects of indomethacin and ketamine on hippocampus neurones in Mongolian gerbils

Pharmacology & Toxicology
E N Petersen

Abstract

Bilateral occlusion of the carotid arteries of Mongolian gerbils for 10 min. resulted in a consistent pattern of degeneration of hippocampal CA1 neurons. Administration of the non-competitive NMDA antagonist ketamine (100 mg/kg intraperitoneally) 30 min. before the occlusion almost entirely prevented degeneration of CA1 neurones. Indomethacin 5 mg/kg intraperitoneally had no influence on the degeneration, either administered 30 min. before or 15 min. after occlusion. The production of prostaglandins from the NMDA receptor stimulation does not seem to be crucial for the development of the ischaemic lesions at least in the hours immediately following occlusion. Indomethacin did not reduce the anti-ischaemic effect of ketamine in the doses presumably necessary to reduce the increase in intracranial pressure induced by ketamine.

References

Feb 14, 1979·Biochemical and Biophysical Research Communications·R J Gaudet, L Levine
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E OzyurtJ McCulloch
Jun 1, 1986·The Australian and New Zealand Journal of Psychiatry·J J Wright, R R Kydd
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M CavazzutiG C Barbieri
Jun 14, 1988·Brain Research·F W MarcouxM A Dominick
Dec 1, 1987·Developmental Medicine and Child Neurology·D H EvansL N Archer
Dec 1, 1974·Anesthesiology·K HougaardP Brodersen
Nov 12, 1981·The New England Journal of Medicine·P L FriedmanW Grossman

❮ Previous
Next ❯

Citations

Aug 1, 1995·Progress in Neurobiology·H Katsuki, S Okuda
Dec 12, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C IadecolaM E Ross

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.