Anti-JC virus seroprevalence in a Finnish MS cohort

Acta Neurologica Scandinavica
Marcin KolasaIrina Elovaara

Abstract

The risk of progressive multifocal leukoencephalopathy (PML) caused by the JC virus (JCV) is increased in patients with multiple sclerosis receiving biological therapies. To determine the seroprevalence of anti-JCV antibodies in Finnish patients with multiple sclerosis (MS) and clinically isolated syndrome and to assess the clinical risk factors for JCV seropositivity. The JCV seroprevalence was analyzed in 503 patients using a second-generation two-step ELISA. Sixty-seven patients underwent longitudinal serological evaluation over 4.5 years. The overall seroprevalence of JCV was 57.4%. The seropositivity was higher in men than in women, tended to increase with age, and was not affected by different immunomodulatory therapies. However, in patients with ongoing natalizumab treatment (n = 72), the anti-JCV antibody screening index was lower than in patients without such therapy [median 0.3 (range 0.1-3.1) vs 0.6 (0.1-3.1), respectively, P = 0.01]. Over 4.5 years, 4/19 (21%) initially seronegative patients converted to seropositivity, whereas 4/48 (8.3%) initially seropositive patients reverted to seronegativity. Fluctuations in serostatus were observed in 3/67 patients. The study confirmed a high anti-JCV antibody prevalence in p...Continue Reading

References

Jul 15, 2003·Journal of Medical Virology·Wendy A KnowlesElizabeth Miller
May 4, 2005·Pharmacology & Therapeutics·Jaime ImitolaSamia J Khoury
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Mar 28, 2009·PLoS Pathogens·Jaime M KeanRobert L Garcea
May 11, 2010·European Neurology·Norman PutzkiErnst Kreuzfelder
Aug 26, 2010·Annals of Neurology·Leonid GorelikMeena Subramanyam
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Jan 24, 2012·Lancet Neurology·David H MillerOlga Ciccarelli
Apr 25, 2012·Journal of Neurology·Olivier OutteryckJérôme de Sèze
May 18, 2012·The New England Journal of Medicine·Gary BloomgrenCarmen Bozic
Sep 18, 2012·Journal of Neuroinflammation·Jeppe Romme ChristensenFinn Sellebjerg
Nov 7, 2012·JAMA Neurology·Richard RudickLawrence Steinman
Feb 27, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Rebecca C SelterBernhard Hemmer
Mar 6, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Tomas OlssonDorothea Buck
Mar 7, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Clemens WarnkeAnna Fogdell-Hahn
Mar 8, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Peter LeeMeena Subramanyam
Mar 26, 2013·Annals of Neurology·Joseph R BergerRobert J Danaher
Aug 28, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Maria Inmaculada Dominguez-MozoRoberto Alvarez-Lafuente
Sep 28, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Olivier OutteryckPatrick Vermersch
Dec 4, 2013·Journal of Neurovirology·Sarah Beltrami, Jennifer Gordon
Jun 5, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C BozicB Ticho

❮ Previous
Next ❯

Citations

Mar 19, 2016·Expert Review of Neurotherapeutics·Maria Rasenack, Tobias Derfuss
Mar 24, 2016·Expert Review of Neurotherapeutics·Olivier Outteryck
Oct 22, 2016·Acta Neurologica Scandinavica·M CambronP Vermersch
Nov 18, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jan KolcavaPavel Stourac
Dec 3, 2020·Journal of Clinical Medicine·Robert BonekKonrad Rejdak
Nov 11, 2020·La Revue de médecine interne·A Moulignier, A Lecler
Oct 20, 2019·Journal of the Neurological Sciences·Maria José SáUNKNOWN JUSTIFY Investigators
May 6, 2021·Therapeutic Advances in Neurological Disorders·Christopher M DwyerAnneke van der Walt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Neurology, Neurosurgery, and Psychiatry
Clemens WarnkeAnna Fogdell-Hahn
European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
C BozicBarry Ticho
Annals of Neurology
Joseph R BergerRobert J Danaher
Multiple Sclerosis : Clinical and Laboratory Research
Clemens WarnkeOrtwin Adams
© 2021 Meta ULC. All rights reserved