PMID: 16625974Apr 22, 2006Paper

Anti Kell allo-antibody in a thalassaemic

Indian Journal of Pathology & Microbiology
Beenu ThakralR K Marwaha

Abstract

We describe a case of incidental detection of anti Kell antibody in a child with transfusion dependent thalassaemia. Kell antibody detection may be missed by routine indirect antiglobulin test (IAT) crossmatch procedure because of low prevalence of Kell antigen in the general population. A false negative result can be avoided by using sensitive cross matching techniques and screening cells representing antigens in homozygous state, against all clinically significant antibodies. A transfusion alert card describing the nature of antibody and future transfusion policy should be given to such allo-immunized patients.

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