Anti-Ku antibodies: Clinical, genetic and diagnostic insights

Autoimmunity Reviews
C BeliznaH Lévesque

Abstract

Anti-Ku antibodies are reported in various connective tissue diseases and the Ku complex can be responsible for a very strong autoimmune answer in autoimmune disease. Nowadays, anti-Ku antibodies are detected by ELISA, counterimmunoelectrophoresis (CIE), immunoblot (IB) and new highly performant techniques. Although the prevalence of anti-Ku antibodies is not homogenous, depending on several features such as disease type, genetic and geographical clustering, and also method of detection, they could be found in 55% overlap PM/systemic sclerosis patients. Moreover, anti-Ku antibodies are not associated with a particular clinical outcome, and especially with cancer related to myositis.

References

Feb 1, 1992·Arthritis and Rheumatism·J D ReveilleF C Arnett
Jan 1, 1995·International Archives of Allergy and Immunology·A SzczeklikM Milewski
Mar 15, 1996·The Journal of Clinical Investigation·A SuwaJ A Hardin
Jul 1, 1997·Arthritis and Rheumatism·I Hausmanowa-PetrusewiczS Jablonska
Feb 14, 1998·The Journal of Biological Chemistry·J WangW H Reeves
Oct 29, 2000·Experimental Gerontology·V A BohrR Brosh
Nov 2, 2001·Frontiers in Bioscience : a Journal and Virtual Library·Y Takeda, W S Dynan
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Micah T McClainJudith A James
Oct 17, 2003·The New England Journal of Medicine·Melissa R ArbuckleJohn B Harley
Jul 10, 2004·Immunological Reviews·Katheryn MeekSusan P Lees-Miller
Sep 1, 2004·Mechanisms of Ageing and Development·Lucio Comai, Baomin Li
May 17, 2005·Autoimmunity Reviews·Félix Fernández MadridJohn E Tomkiel
Jun 17, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Melita VidakovićJuergen Bode
Aug 6, 2005·Autoimmunity Reviews·D HofGer J M Pruijn
Aug 8, 2006·Autoimmunity Reviews·John D Reveille
Nov 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Pierre-Olivier MariDik C van Gent
Feb 24, 2007·Autoimmunity Reviews·Lisa G Rider
Mar 30, 2007·Annals of the Rheumatic Diseases·Hector ChinoyRobert G Cooper
Jun 1, 2007·Autoimmunity Reviews·Danilo VillaltaNicola Bizzaro
Jul 24, 2007·Autoimmunity Reviews·Michael Mahler, Reinout Raijmakers
Jul 12, 2008·Autoimmunity Reviews·Martial KoenigJean-Luc Senécal
Aug 14, 2008·Autoimmunity Reviews·Claudio LunardiAntonio Puccetti
Aug 19, 2008·Autoimmunity Reviews·Silvia Bellando RandoneMarco Matucci Cerinic
Mar 17, 2009·Autoimmunity Reviews·Johan RönnelidIngrid E Lundberg
Apr 28, 2009·Autoimmunity Reviews·Tamás CzömpölyPéter Németh
Apr 28, 2009·Autoimmunity Reviews·Anna GhirardelloAndrea Doria
Nov 13, 2009·Autoimmunity Reviews·Brigitte Ranque, Luc Mouthon
Dec 23, 2009·Autoimmunity Reviews·S ZampieriA Doria

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Citations

Apr 11, 2012·Autoimmunity Reviews·Carolina Duarte-ReyM Eric Gershwin
Nov 15, 2011·Rheumatic Diseases Clinics of North America·Félix Fernández Madrid, Marie-Claire Maroun
Jul 19, 2011·Autoimmunity Reviews·Carlo Selmi
Jan 4, 2012·The Journal of Dermatology·Charisse M OrmeTamara Lazic
Jun 30, 2012·Autoimmunity Reviews·Sonal MehraMarvin J Fritzler
Jun 30, 2012·Autoimmunity Reviews·Luca IaccarinoAndrea Doria
Mar 3, 2012·Autoimmunity Reviews·Michael MahlerMarvin J Fritzler
Jul 17, 2016·Best Practice & Research. Clinical Rheumatology·Joanna TieuVidya Limaye
Jul 28, 2017·Autoimmunity·Christos LiaskosLazaros I Sakkas
Mar 16, 2018·Clinical and Molecular Allergy : CMA·Boaz PaltererPaola Parronchi
Sep 2, 2016·Medicine·S HoaUNKNOWN Canadian Scleroderma Research Group (CSRG); Australian Scleroderma Interest Group (ASIG); Genetics versus Environment in Scl
May 15, 2018·The Journal of Pathology·Vassilis G GorgoulisIoannis P Trougakos
May 18, 2017·Frontiers in Immunology·Maria Carmina CastielloMarita Bosticardo
Nov 26, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Chiara SistFrancesco Teatini
Apr 16, 2021·Cellular and Molecular Life Sciences : CMLS·Sanna AbbasiCaroline Schild-Poulter
Apr 14, 2018·Joint, Bone, Spine : Revue Du Rhumatisme·Sébastien De Almeida ChavesLéonardo Astudillo

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