Anti-Ku antibodies. Study of prévalence and of clinical meaning

La Revue de médecine interne
O Beyne-RauzyD Adoue

Abstract

Auto-immunity against Ku nuclear antigens is rare and clinical meaning remains badly estimated. Our study is for purposes: to appreciate the prévalence of antibodies anti-Ku within the framework of the search for antinuclear antibodies and to clarify clinical and biological relations associated to this auto-immunity. A retrospective study of a series of 10,000 searches for antinuclear antibodies studies the prévalence of the auto-immunity anti-Ku and a retrospective analysis of the data found at the patients bearers of an anti-Ku identifies clinical and biological signs associated with this antibody. Prévalence anti-Ku is low (1/3493 case of antinuclear antibodies) and association is possible with in a myositic process through variable auto-immune contexts (overlap syndrome) of relative good preview. Auto-immunity anti-Ku is so characterized with its weak prévalence, a possible observation during different auto-immune diseases with an obvious frequency of the overlap syndrome often concerning a process myositic. Finally a weak évolutivité seems to characterize the auto-immune diseases of the patients with anti-Ku antibodies.

Citations

Jun 27, 2006·La Revue de médecine interne·C GaudinO Beyne-Rauzy
Mar 28, 2017·Joint, Bone, Spine : Revue Du Rhumatisme·Alain MeyerJean Sibilia
Dec 6, 2019·QJM : Monthly Journal of the Association of Physicians·Taro HorinoYoshio Terada

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