Anti-leishmanial activity of a topical miltefosine gel in experimental models of New World cutaneous leishmaniasis

The Journal of Antimicrobial Chemotherapy
Laura Fernanda NeiraPatricia Escobar

Abstract

Topical treatment for cutaneous leishmaniasis (CL) would be useful for treatment of some forms of the disease. The aim of this study was to develop and then evaluate a topical miltefosine gel for anti-leishmanial activity and toxicity in BALB/c mice infected with New World (NW)-CL species. A Carbopol-based gel of 0.5% miltefosine was prepared and physicochemical (colour, pH, consistency and antioxidant activity) and stability properties were determined using standard methodologies. Anti-leishmanial activities for Leishmania (Viannia) braziliensis and Leishmania (Viannia) panamensis were determined both in cultured parasites and in infected BALB/c mice after topical miltefosine gel treatment administered for 20 days. The gel was evaluated for its capacity to inhibit parasites at a 50% level after 3 days of treatment in vitro, and its capacity to reduce lesion size (mm2) and parasitic load after 20 days of treatment. Dermal irritation, contact hypersensitivity (CHS), clinical biochemical profile and the weight of the animals were determined after treatment. The 0.5% miltefosine gel was transparent, homogeneous, colourless, of neutral pH, spreadable and stable at 4°C for at least 3 months. It was active against parasites in vitro ...Continue Reading

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Citations

Jul 23, 2019·Natural Product Research·Mariana Gomes Vidal SampaioMárcia Vanusa Da Silva
Jul 18, 2020·Drug Delivery and Translational Research·Ana Paula Dos Santos MatosEduardo Ricci-Júnior
Jan 28, 2021·Drug Delivery and Translational Research·Ma Florencia PeraltaDolores C Carrer
Mar 4, 2021·PLoS Neglected Tropical Diseases·Marium AzimSyed Ishtiaq Anjum

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