Anti-LINGO-1 antibody treatment improves chronic stress-induced spatial memory impairments and oligodendrocyte loss in the hippocampus.

Behavioural Brain Research
Chunmao YangYong Tang

Abstract

Chronic exposure to stressful conditions may affect spatial learning and memory abilities and the brain structure, and disruptions in oligodendrocyte function may cause cognitive dysfunction. Leucine-rich repeat and immunoglobulin-like domain-containing protein 1 (LINGO-1) is a potent negative regulator of oligodendrocytes and axon myelination. However, the questions we sought to answer in this study are whether hippocampal oligodendrocytes are involved in the pathological process of spatial learning and memory impairments induced by chronic stress (CS) and whether antibodies targeting LINGO-1 improve stress-induced spatial learning and memory impairments by protecting the hippocampal oligodendrocytes in stressed rats. After 4 weeks of CS, rats were randomly divided into either the CS standard group or anti-LINGO-1 group. The anti-LINGO-1 group was treated with an anti-LINGO-1 antibody (8 mg/kg) for 3 weeks; all rats were assessed in the Morris water maze. Immunohistochemical staining and modern stereological methods were used to precisely quantify the total number of 2',3'-cyclic nucleotide 3'-phosphodiesterase-positive (CNPase+) oligodendrocytes in each subregion of the hippocampus. At the behavioural level, after three weeks...Continue Reading

References

May 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenA Vesterby
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Jan 29, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B S McEwen
Aug 24, 2001·Schizophrenia Research·J C DreherY Burnod
Jul 2, 2002·Nature Genetics·Douglas E VetterKuo-Fen Lee
Aug 27, 2002·Neuron·Neil BurgessJohn O'Keefe
Apr 22, 2004·Schizophrenia Research·Susan R McGurkRobert Kern
May 17, 2005·Nature Neuroscience·Sha MiR Blake Pepinsky
Mar 8, 2006·Pharmacology, Biochemistry, and Behavior·Li SongKinzo Matsumoto
Mar 9, 2006·Behavioral and Brain Functions : BBF·Rebecca M ShanskyAmy F T Arnsten
Jan 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xinhua LeeSha Mi
Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Oct 11, 2007·JAMA : the Journal of the American Medical Association·Sheldon CohenGregory E Miller
May 13, 2008·The International Journal of Biochemistry & Cell Biology·Sha MiRobert H Miller
Apr 3, 2009·Nature Reviews. Neuroscience·Marian Joëls, Tallie Z Baram
Apr 21, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gilberto Fernando Xavier, Valéria Catelli Infantozzi Costa
Jun 16, 2009·Nature Neuroscience·Mattias P Karlsson, Loren M Frank
Aug 17, 2010·Annual Review of Medicine·Bruce S McEwen, Peter J Gianaros
Feb 2, 2011·Experimental Neurology·Timothy J Schoenfeld, Elizabeth Gould
Mar 8, 2011·Neurobiology of Learning and Memory·Marie-France MarinSonia J Lupien
Sep 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiao-Dong WangMathias V Schmidt
Aug 7, 2013·The International Journal of Neuropsychopharmacology·Edward RamAvi Avital
Apr 30, 2014·Frontiers of Neurology and Neuroscience·Katja Wingenfeld, Oliver T Wolf
Jun 17, 2015·Physiology & Behavior·Chloe J A SheaRyan Jankord
Jul 6, 2015·Neuroscience and Biobehavioral Reviews·Jessica L Andrews, Francesca Fernandez-Enright
Jan 12, 2016·Reviews in the Neurosciences·Ivan ZaletelNela Puškaš
Aug 30, 2017·Frontiers in Cellular Neuroscience·Swananda MaratheLavinia Alberi

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