Anti-lipolytic effects of insulin in African American and white prepubertal boys

Obesity Research
B A GowerM I Goran

Abstract

Relative to whites, African Americans have lower circulating triglycerides (TG) and greater highdensity lipoprotein cholesterol. The metabolic basis for this difference is not known. This study was conducted to test the hypothesis that insulin-induced suppression of free fatty acids (FFA) results in lower serum TG in African American versus white prepubertal children. Insulin, FFA, and TG were determined at baseline and during a frequently sampled, intravenous glucose tolerance test in eight African American and eight white prepubertal males pair-matched for whole-body insulin sensitivity. Baseline TG was lower in African Americans (0.43 +/- 0.10 vs. 0.79 +/- 0.37 mM/L; mean +/- SD; p < 0.01). African Americans had higher peak insulin (218 +/- 102 vs. 100 +/- 30 pM/L; mean +/- SD; p < 0.01) and a greater acute insulin response (9282 +/- 4272 vs. 4230 +/- 1326 pM/L x 10 minutes; mean +/- SD; p < 0.05). FFA and TG values determined at the FFA nadir were lower in African Americans (0.26 +/- 0.02 vs. 0.30 +/- 0.03 mEq/L; mean +/- SD; p < 0.01 for FFA nadir and 0.49 +/- 0.07 vs. 0.77 +/- 0.33 mM/L; mean +/- SD; p < 0.05 for TG). Among all subjects, FFA nadir was correlated with peak insulin (r = -0.54; p < 0.05). After adjusting for...Continue Reading

References

May 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R J DeckelbaumS Eisenberg
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Apr 11, 1996·The New England Journal of Medicine·J P DesprésP J Lupien

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Citations

May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Barbara A GowerMichael I Goran
May 1, 2020·Journal of Internal Medicine·B A Gower, L A Fowler
Jan 1, 2012·Expert Review of Endocrinology & Metabolism·Amy R Bentley, Charles N Rotimi

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