Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds.

Malaria Journal
Awet Alem TeklemichaelKenji Hirayama

Abstract

Herbal medicine has been a rich source of new drugs exemplified by quinine and artemisinin. In this study, a variety of Japanese traditional herbal medicine ('Kampo') were examined for their potential anti-malarial activities. A comprehensive screening methods were designed to identify novel anti-malarial drugs from a library of Kampo herbal extracts (n = 120) and related compounds (n = 96). The anti-malarial activity was initially evaluated in vitro against chloroquine/mefloquine-sensitive (3D7) and-resistant (Dd2) strains of Plasmodium falciparum. The cytotoxicity was also evaluated using primary adult mouse brain cells. After being selected through the first in vitro assay, positive extracts and compounds were examined for possible in vivo anti-malarial activity. Out of 120 herbal extracts, Coptis rhizome showed the highest anti-malarial activity (IC50 1.9 µg/mL of 3D7 and 4.85 µg/mL of Dd2) with a high selectivity index (SI) > 263 (3D7) and > 103 (Dd2). Three major chlorinated compounds (coptisine, berberine, and palmatine) related to Coptis rhizome also showed anti-malarial activities with IC50 1.1, 2.6, and 6.0 µM (against 3D7) and 3.1, 6.3, and 11.8 µM (against Dd2), respectively. Among them, coptisine chloride exhibited...Continue Reading

References

Jun 22, 1978·Nature·W Trager, J B Jenson
Feb 1, 1997·International Journal for Parasitology·M Foley, L Tilley
Jun 3, 2004·Nature Reviews. Drug Discovery·David A FidockSolomon Nwaka
Aug 1, 1987·Parasitology Today·D Payne
Nov 4, 2008·Journal of Ethnopharmacology·Sanne de RidderRobert Verpoorte
Mar 11, 2011·Chinese Journal of Integrative Medicine·Yoshiharu MotooKiichiro Tsutani
May 26, 2011·Malaria Journal·Jane AchanUmberto D'Alessandro
Apr 24, 2012·Journal of Proteomics·Hsiu-Chuan ChouHong-Lin Chan
Nov 6, 2012·BMC Complementary and Alternative Medicine·Makoto AraiShun-ichiro Izumi
Jan 16, 2013·Antimicrobial Agents and Chemotherapy·Danny W WilsonJames G Beeson
Apr 5, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·S YakuboK Watanabe
Jul 11, 2014·Transactions of the Royal Society of Tropical Medicine and Hygiene·Abraham P MnzavaClive J Shiff
Mar 22, 2016·Tropical Parasitology·Hiasindh Ashmi Antony, Subhash Chandra Parija
May 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haidan YuanGuangchun Piao
May 18, 2016·The American Journal of Tropical Medicine and Hygiene·G Dennis Shanks
Aug 16, 2016·Frontiers in Pharmacology·Katrin M HoffmannGünter Gisselmann
Sep 14, 2016·BMC Medical Informatics and Decision Making·Tetsuhiro YoshinoKenji Watanabe
Feb 9, 2017·Journal of the Royal Society of Medicine·G GachelinI Chalmers
Apr 8, 2017·Nature Medicine·Steven M CorselloTodd R Golub
Aug 2, 2017·Nature Plants·Fu-Shuang Li, Jing-Ke Weng
Feb 6, 2018·The Lancet Infectious Diseases·Roberto AmatoDominic P Kwiatkowski
Feb 10, 2018·Malaria Journal·Christian NsanzabanaIveth J González
Feb 15, 2018·Antimicrobial Agents and Chemotherapy·Farhana MosaddequeKenji Hirayama
Apr 1, 2018·The Lancet Infectious Diseases·N Regina Rabinovich
Aug 2, 2018·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Thomas F Whayne
Sep 10, 2018·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Bing HanXuegang Li
Oct 13, 2018·Nature Reviews. Drug Discovery·Sudeep PushpakomMunir Pirmohamed
Nov 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shuilian FuTie Hong
Jan 3, 2019·Expert Review of Vaccines·K L WilsonM Plebanski
Jul 8, 2019·European Journal of Pharmacology·Li-Li ShiGuan-Hua Du
Dec 7, 2019·Malaria Journal·Nasir Tajuddeen, Fanie R Van Heerden

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Citations

Jul 1, 2021·Journal of Natural Medicines·Yasinjan HashimKatsuko Komatsu
Sep 18, 2021·Journal of Natural Medicines·Yasinjan HashimKatsuko Komatsu
Jan 11, 2022·Journal of Natural Medicines·Mya Myat Ngwe TunKouichi Morita

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