Anti-MET targeted therapy has come of age: the first durable complete response with MetMAb in metastatic gastric cancer

Cancer Discovery
Yan Feng, Patrick C Ma

Abstract

The MET/hepatocyte growth factor (HGF) signaling pathway plays important roles in oncogenesis and tumor progression in a variety of human cancers. MET/HGF drives an invasive signaling program that can be dysregulated in human cancers through a number of activating mechanisms, including mutations, overexpression, amplification, alternative splicing, and HGF ligand-induced autocrine/paracrine loop signaling. As a testimony of MET-targeting therapeutics is beginning to come to clinical fruition, Catenacci and colleagues report the first case of durable complete response under an anti-MET receptor monoclonal antibody, MetMAb, in a patient with chemotherapy-refractory, advanced gastric cancer metastatic to the liver, found to have high MET gene polysomy and remarkably high serum HGF level. Serum and tissue studies also revealed predictive biomarkers for therapeutic response to MET inhibition.

References

Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tobias MartensKatrin Lamszus
Aug 19, 2008·Genes, Chromosomes & Cancer·Patrick C MaRavi Salgia
Dec 9, 2009·Journal of Medicinal Chemistry·Chunying WuYanming Wang
Sep 14, 2010·The Journal of Biological Chemistry·Giovanni PacchianaElisa Vigna
Nov 26, 2010·Nature Reviews. Molecular Cell Biology·Livio TrusolinoPaolo M Comoglio
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 31, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sai-Hong Ignatius OuA John Iafrate

❮ Previous
Next ❯

Citations

Feb 2, 2013·Chinese Journal of Cancer·Hsin-Hui Tseng, Biao He
Sep 4, 2016·Journal of Translational Medicine·Giulia M StellaSilvia Benvenuti
Feb 9, 2020·Oncogene·Jonas P KochMichaela Medová
Apr 19, 2019·JCO Precision Oncology·Daniel V T Catenacci
Nov 10, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Seokhwi KimDakeun Lee
Nov 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paola FrancicaMichaela Medová

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.