Anti-metastatic activity of Acanthopanax senticosus extract and its possible immunological mechanism of action

Journal of Ethnopharmacology
Taek Joon YoonWoo-Mun Park

Abstract

Antitumor and immunomodulatory activities of an aqueous extract (GF100) of Acanthopanax senticosus were examined. In experimental lung metastasis of colon26-M3.1 carcinoma cells, intravenous (i.v.) administration of GF100 2 days before tumor inoculation significantly inhibited lung metastasis in a dose-dependent manner. The i.v. administration of GF100 also exhibited the therapeutic effect on tumor metastasis of colon26-M3.1 cells, when it was injected 1 day after tumor inoculation. In an in vitro cytotoxicity analysis, GF100 at the concentration up to 1000 microg/ml did not affect the growth of colon26-M3.1 cells. In contrast, GF100 enhanced the responsiveness to a mitogen, concanavalin A (ConA), of splenocytes in a dose-dependent manner. Peritoneal macrophage stimulated with GF100 produced various cytokines such as IL-1beta, TNF-alpha, IL-12 and IFN-gamma in an in vitro experiment. The macrophages obtained from the mice which were injected with GF100 (500 microg) 3 days before the assay showed significantly higher tumoricidal activity against tumor cells than that of the untreated macrophages. In addition, the i.v. administration of GF100 significantly augmented NK cytotoxicity to Yac-1 cells. The depletion of NK cells by inj...Continue Reading

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Citations

Aug 12, 2008·Applied Microbiology and Biotechnology·Taek Joon YoonHyung Joo Suh
May 20, 2009·Journal of Bone and Mineral Metabolism·You-Cheol HwangHo Yeon Chung
Sep 2, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·José A Olalde Rangel
Apr 9, 2014·Canadian Journal of Physiology and Pharmacology·Hyun Jeong KimHeonyong Park
Jul 10, 2014·Applied Microbiology and Biotechnology·Hosakatte Niranjana MurthyKee-Yoeup Paek
Jul 26, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong Wook LimYun Tai Kim
Mar 27, 2010·Chemico-biological Interactions·Eui-Baek ByunJu-Woon Lee
Jul 6, 2014·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Bhaktaprasad Gaire, Dongwook Lim
Mar 20, 2016·Experimental Hematology·Qing-Yuan WangJi-Hua Zhong
Dec 11, 2007·International Immunopharmacology·Taek Joon YoonKwang Ho Lee
Apr 6, 2005·Drug Discovery Today·Bhushan Patwardhan, Manish Gautam
May 19, 2012·International Journal of Molecular Sciences·Yu-Jin HwangKyung-A Hwang
Dec 29, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xue-Ling ZhangXin-Wei Liu
Mar 4, 2010·Nutrition Research and Practice·Ae-Jung KimSang-Do Ha
May 17, 2019·The American Journal of Chinese Medicine·Dae-Young LeeKwang-Soon Shin
Feb 13, 2018·Experimental and Therapeutic Medicine·Qinglong MengYueying Ren
Jan 17, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yaoyao DaiJunfeng Zhu
Nov 18, 2016·The American Journal of Chinese Medicine·Ting LiShu-Lin Liu

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