Anti-methicillin-resistance Staphylococcus aureus (MRSA) compounds from Bauhinia kockiana Korth. And their mechanism of antibacterial activity

BMC Complementary and Alternative Medicine
Yik Ling ChewJoo Kheng Goh

Abstract

Bauhinia kockiana originates from Peninsular Malaysia and it is grown as a garden ornamental plant. Our previous study reported that this plant exhibited fairly strong antioxidant and antimicrobial activities. This paper focused on the assessment of the antibacterial activity of B. kockiana towards methicillin-resistance Staphylococcus aureus (MRSA), to purify and to identify the antibacterial compounds, and to determine the mechanism of antibacterial activity. Antibacterial activity of B. kockiana flower was evaluated qualitatively and quantitatively using disc diffusion assay and microbroth dilution method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of extracts were examined. Phytochemical analysis was performed to determine the classes of phytochemicals in the extracts. Bioactivity guided isolation was employed to purify the antibacterial agents and identified via various spectroscopy methods. Scanning electron microscopy (SEM) technique was used to evaluate the antibacterial mechanism of extract and compounds isolated. B. kockiana flower was found to exhibit fairly strong antibacterial activity towards both strains of MRSA bacteria used, MIC varies from 62.5-250 μg/mL. Tannins and fl...Continue Reading

References

Dec 3, 1998·Journal of Natural Products·T NishiokaY Aoyama
Feb 24, 2001·Bioorganic & Medicinal Chemistry Letters·I KuboK Fujita
Jan 5, 2002·Bioorganic & Medicinal Chemistry Letters·Isao KuboKen'ichi Fujita
Oct 31, 2002·Journal of Agricultural and Food Chemistry·Isao KuboKen-Ichi Nihei
Mar 5, 2004·Journal of Agricultural and Food Chemistry·Isao KuboAtsuko Nihei
Jan 28, 2005·Antimicrobial Agents and Chemotherapy·Hirofumi ShibataTomihiko Higuti
Sep 19, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter C Appelbaum
Nov 13, 2007·Bioorganic & Medicinal Chemistry·Zhuo ChenXia Zhou
Aug 21, 2010·Journal of Medical Microbiology·Shanmugam Hemaiswarya, Mukesh Doble
Mar 26, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Laura Freire-MoranUNKNOWN ECDC-EMA Working Group
Dec 21, 2012·Phytotherapy Research : PTR·Ki-Suk KimHyeung-Jin Jang
Feb 7, 2014·Current Biology : CB·Michael Gross
Feb 13, 2014·Journal of Infection in Developing Countries·Zhabiz GolkarDonald Gene Pace
Oct 4, 2014·Frontiers in Public Health·Carolyn Anne MichaelMaurizio Labbate
Nov 6, 2014·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Yik Ling ChewJoo Kheng Goh
Apr 28, 2016·Biochimica Et Biophysica Acta·Małgorzata Jurak, José Miñones
Jul 3, 2016·BMC Complementary and Alternative Medicine·Kun LiShouyu Wang

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Citations

Sep 6, 2018·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Jinfeng YangMyong Jo Kim
Feb 18, 2020·Clinical and Experimental Pharmacology & Physiology·Muhammad AkramFahad Said Khan
Dec 7, 2018·Critical Reviews in Food Science and Nutrition·Jiao LiTian Ding
Aug 8, 2020·MicrobiologyOpen·Lúcia B CavalcaHenrique Ferreira
Jul 25, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·F J Álvarez-MartínezV Micol

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Methods Mentioned

BETA
scanning electron microscopy
nuclear magnetic resonance
NMR

Software Mentioned

SPSS

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