Jun 2, 2020

Anti-microbial and anti-inflammatory effects of Cheonwangbosim-dan against Helicobacter pylori -induced gastritis

Journal of Veterinary Science
Hee Seon ParkHyo Jung Kwon

Abstract

There are various Helicobacter species colonizing the stomachs of animals. Although Helicobacter species usually cause asymptomatic infection in the hosts, clinical signs can occur due to gastritis associated with Helicobacter in animals. Among them, Helicobacter pylori is strongly associated with chronic gastritis, gastric ulcers, and gastric cancers. As the standard therapies used to treat H. pylori have proven insufficient, alternative options are needed to prevent and eradicate the diseases associated with this bacterium. Cheonwangbosim-dan (CBD), a traditional herbal formula that is popular in East Asia, has been commonly used for arterial or auricular flutter, neurosis, insomnia, and cardiac malfunction-induced disease. The present study investigated the antimicrobial effect of CBD on H. pylori-infected human gastric carcinoma AGS cells and model mice. AGS cells were infected with H. pylori and treated with a variety of concentrations of CBD or antibiotics. Mice were given 3 oral inoculations with H. pylori and then dosed with CBD (100 or 500 mg/kg) for 4 weeks or with standard antibiotics for 1 week. One week after the last treatment, gastric samples were collected and examined by histopathological analysis, real-time qu...Continue Reading

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Mentioned in this Paper

Nitric Oxide Synthase Type II
Malfunction from Artificial Pacing
Malondialdehyde
Chronic Gastritis
Quantitative Real-Time Polymerase Chain Reaction
Helicobacter pylori
Injury of Stomach
Study
Atrial Flutter
Stomach Carcinoma

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