PMID: 6975242Jan 1, 1981Paper

Anti-mite IgE antibody production in vitro by peripheral blood lymphocytes from mite-sensitive atopic patients

International Archives of Allergy and Applied Immunology
Y YanagiharaT Miyamoto

Abstract

Anti-mite IgE antibody production in vitro was investigated using peripheral blood lymphocytes (PBL) from mite-sensitive patients with bronchial asthma. Preculture of PBL with the mite antigen, which induced the remarkable cell proliferation, resulted in a marked decrease of the IgE antibody production directed to mite but not to unrelated antigens. Anti-mite IgE antibody formation was not inhibited by autologous or allogeneic T cells stimulated with the mite antigen. The spontaneous production of IgE antibody was observed when fractionated B cells were cultured alone or with pokeweed mitogen (PWM), but was suppressed when they were precultured with the antigen. Coculture of autologous T cells with B cells showed a considerable augmentation of anti-mite IgE antibody formation. The enhancing activity of autologous T cells was not observed when B cells were irradiated at 1,000 rad. The spontaneous IgE antibody production by B cells alone was radioresistant. Both mitotic inhibitors and 1,000 to 2,000 rad of gama-irradiation did not significantly suppress the spontaneous anti-mite IgE antibody production by B cells.

Citations

Feb 1, 1989·Experimental Parasitology·N Watanabe, A Kobayashi
Dec 26, 2002·Annual Review of Immunology·Hannah J GouldLyn Smurthwaite

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