Anti-MOG and Anti-AQP4 positive neuromyelitis optica spectrum disorder in a patient with myasthenia gravis

Multiple Sclerosis and Related Disorders
Molly BatesZain Guduru

Abstract

Aquaporin 4 antibody (anti-AQP4) positive neuromyelitis optica spectrum disorder (NMOSD) is known to occur in the setting of myasthenia gravis (MG). However, comorbid MG with myelin oligodendrocyte glycoprotein antibody (anti-MOG) positive NMOSD has not been reported. We present a case of anti-MOG and anti-AQP4 positive NMOSD in a patient with long-standing MG. The patient presented with acute right-sided weakness with MRI demonstrating extensive spinal cord edema extending from T2 to the medulla with associated contrast enhancement. To our knowledge, this is the first reported case of anti-MOG and anti-AQP4 positive NMOSD in a patient with known MG.

References

Jan 15, 2014·Neurology·Douglas Kazutoshi SatoKazuo Fujihara
Oct 26, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Romana HöftbergerAlbert Saiz
Jan 10, 2018·Frontiers in Immunology·Zhen Wang, Yaping Yan
Nov 27, 2018·Multiple Sclerosis and Related Disorders·Sareh ShahmohammadiAbdorreza Naser Moghadasi

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