Anti-mu treatment suppresses immunoglobulin light-chain gene expression and Peyer's patch development

Molecular Immunology
G E WoloschakM Rodriguez

Abstract

Anti-mu treated mice have been used extensively as a model for suppressed B-cell development [Murgita R. A., Mattioli C. A. and Tomasi T. B., Jr. (1973) J. exp. Med. 138, 209; Manning D. D. (1975) J. Reticuloendothel. Soc. 18, 63; Manning D. D. and Jutila J. W. (1972) J. Immun. 108, 282; Janeway C. A., Jr., Murgita R. A., Weinbaum F. I., Asofsky R. and Wigzell H. (1977) Proc. natn. Acad. Sci. U.S.A. 74, 4582; Hayglass K. T., Naides S. J., Benacerraf B. and Sy M.-S. (1985) J. Molec. Cell. Immun. 2, 107; Manning D. D. (1972) J. Immun. 109, 1152; Cooper M. D., Kearney J. F., Gathings W. E. and Lawton A. R. (1980) Immun. Rev. 52, 29; Burrows P. D., Kearney J. F., Lawton A. R. and Cooper M. D. (1978) J. Immun. 120, 1526]. However, little molecular evaluation has been performed on these animals to determine the level at which B-lineage cells are arrested. Experiments reported here were designed to determine the effects of anti-mu treatment of newborn mice on Ig-specific mRNA expression in lymphocyte populations. Newborn CBA/J mice received i.p. injections of goat anti-mu IgG or non-immune goat IgG, every 2 days, from birth until age 4 weeks. The degree of B-cell suppression in anti-mu treated mice was evident by low serum Ig levels a...Continue Reading

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C A JanewayH Wigzell
Feb 1, 1972·The Journal of Experimental Medicine·A R LawtonM D Cooper
Jun 1, 1972·The Journal of Experimental Medicine·D D Manning, J W Jutila
Jan 1, 1984·Experimental Cell Biology·J BamatH R MacDonald
Jan 1, 1980·Immunological Reviews·M D CooperA R Lawton
Jan 1, 1982·The Journal of Experimental Medicine·J L Van Snick, P Coulie

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Citations

Feb 1, 1991·Immunological Investigations·N IvesK Dreher
May 1, 1994·European Journal of Immunology·M A MarcosA Coutinho

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