Anti-Müllerian hormone in association with euploid embryo transfer outcomes

Reproductive Biomedicine Online
Ange WangLynn M Westphal

Abstract

To investigate the association between anti-Müllerian hormone (AMH) concentration and maternal age with single euploid cryopreserved embryo transfer. Retrospective cohort study from 2014 to 2018 at an academic medical centre, including 389 cycles of IVF with 24-chromosome Day 5/6 preimplantation genetic testing for aneuploidies (PGT-A). Multivariate logistic regression was used to study AMH and age in relation to IVF outcomes (positive beta human chorionic gonadotrophin [bHCG], ongoing pregnancy and pregnancy loss rates) for patients with at least one euploid embryo for transfer, controlling for patient and cycle confounders. In this cohort the overall unadjusted positive bHCG rate was 69.2% and ongoing pregnancy rate was 52.7% per transfer, while the pregnancy loss rate was 23.4% per cycle with positive bHCG. Multivariate analysis found that compared with the reference group of AMH 1 to <5 ng/ml, AMH <1 and 5+ did not have any significant difference in positive bHCG (odds ratio, OR 0.65 [0.30-1.44] and 1.27 [0.61-2.65] for AMH <1 and AMH 5+, respectively) or ongoing pregnancy (OR 0.80 [0.43-1.50] and 1.41 [0.68-2.90]). However, AMH <1 had statistically significant lower euploid miscarriage rates compared with the reference gro...Continue Reading

Citations

Jul 25, 2019·Archives of Gynecology and Obstetrics·Ange WangLynn Westphal
Jan 16, 2021·Human Fertility : Journal of the British Fertility Society·Anne-Sophie CornilleTiphaine Lefebvre
Jul 30, 2020·Gynécologie, Obstétrique, Fertilité & Sénologie·C BaronS Hamamah
Apr 15, 2021·Reproductive Biomedicine Online·Angela PipariJuan A Garcia-Velasco
May 1, 2021·Reproductive Biomedicine Online·Elias M Dahdouh, William H Kutteh

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