PMID: 18721496Aug 30, 2008Paper

Anti-mullerian hormone in young women after chemotherapy and infradiaphragmatic radiotherapy for childhood cancer

Pediatric endocrinology, diabetes, and metabolism
Maryna Krawczuk-RybakBeata Zelazowska-Rutkowska

Abstract

Composed anticancer treatment leads to different late effects, such as ovarian failure, causing infertility or premature menopause. was to analyse ovarian function, particularly anti-mullerian hormone levels, in young females after anticancer treatment. We analysed FSH, LH, estradiol and anti-mullerian hormone (AMH) levels on days 3-5 of a menstrual cycle in thirty three cancer survivors in mean age 19.1+/-4.7 years treated in age 12.0+/-5.6 years for Hodgkin Lymphoma (HL) (n=16), nephroblastoma (n=7), soft tissue sarcoma (n=4), germinal tumor (n=3), neuroblastoma (n=2), histiocytosis (n=1). Infradiaphragmatic radiotherapy was needed in 16 patients (10 treated for HL). Results were compared with healthy girls of the same age. The mean values of FSH, LH, E2 and AMH did not differ in all survivors comparing to controls. Patients treated for HL with chemo- and radiotherapy presented higher FSH levels than controls (8.53+/-3.25 vs. 5.8+/-2.03 mIU/ml; p=0.045). Mean AMH levels were lower in all patients that received radiotherapy for the infradiaphragmatic region (17.19+/-14.84 pmol/l) than in controls (29.40+/-13.2 pmol/l; p=0.037). Particular analysis of all cases showed higher (>2 SD) FSH levels in 8 patients: 5 patients treated ...Continue Reading

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