Anti-Müllerian hormone predictive levels to determine the likelihood of ovarian hyper-response in infertile women with polycystic ovarian morphology

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Azadeh Akbari SeneAhad Alizadeh

Abstract

Background: The objective of this study was to investigate how the serum levels of Anti-Müllerian hormone (AMH) in normal-ovulatory infertile women with polycystic ovarian morphology (PCOM) is associated with ovarian hyper-response? Methods: This prospective cohort study was carried out on 100 infertile women with PCOM who were treated by antagonist/agonist-triggered stimulation protocol in Shahid Akbar-Abadi Hospital IVF center, Tehran, Iran. Serum AMH levels were measured before starting the ART cycle and the ovarian hyper-response was evaluated by retrieved oocyte numbers, estradiol levels on triggering day and the incidence of OHSS clinical signs and symptoms. Logistic regression and the area under the curve (AUC) were used to estimate the effects of AMH and accuracy of test. Results: ROC curve analysis showed that AMH had a significant performance to predict ovarian hyper-response in PCOM patients (AUC = 0.73). The estimated threshold value was 4.95 ng/ml, specificity was 74.58% (95%CI: [50.85, 93.22]), and sensitivity was 73.17% (95%CI: [48.78, 92.68]). The results of logistic regression showed that there was a significant interaction between AMH and BMI (P = 0.008) so BMI had a moderation effect. In other words, the AMH ...Continue Reading

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