Anti-myelin-associated glycoprotein IgM antibody titers in neuropathy associated with macroglobulinemia.

Annals of Neurology
E Nobile-OrazioL Baldini

Abstract

Twenty-seven patients with neuropathy and IgM monoclonal gammopathy were tested for antigen specificity of the M-protein and for anti-myelin-associated glycoprotein (MAG) IgM levels by immunoblot. In 16 patients (59.2%) the M-protein reacted with MAG and with cross-reactive glycoconjugates. Anti-MAG IgM titers in these patients ranged between 1:12,800 and 1:100,000. A fainter IgM reactivity with MAG and related glycoconjugates was detected in 3 additional patients with neuropathy, but also in 8 of 24 patients with IgM M-protein without neuropathy (33.3%). This reactivity was not due to the M-protein and corresponded to antibody titers of 1:400 or less in all but 1 patient with a titer of 1:3,200. Low titers of anti-MAG IgM (1:200 or less) were also detected in 17 of 101 control patients without IgM M-proteins (16.8%), while 1 patient with neuropathy of unknown cause had anti-MAG IgMK titers of 1:25,600. In 1 patient with neuropathy and IgM M-protein that was not anti-MAG, the M-protein bound to other antigens in nerve, while in 6, other possible causes or mechanisms for the neuropathy were found. In this study, high titers of anti-MAG IgM antibodies were always associated with neuropathy. The presence of low levels of anti-MAG ...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Aug 1, 1985·Annals of Neurology·M TakatsuL Freddo
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A A IlyasR O Brady
May 1, 1986·Annals of Neurology·N MurrayA J Steck
Jul 1, 1988·Annals of Neurology·E Nobile-OrazioG Scarlato
Feb 1, 1985·The Journal of Clinical Investigation·R S Schwartz, B D Stollar
Apr 1, 1986·Journal of Neuroimmunology·D J O'ShannessyR H Quarles
Jan 1, 1986·Annals of the New York Academy of Sciences·G DighieroS Avrameas
Jan 1, 1970·Acta Neurologica Scandinavica. Supplementum·J Prineas
Oct 18, 1972·Nature: New Biology·S A Rosenberg, G N Rogentine
Oct 27, 1972·Nature·M Rosenberg
Jan 19, 1973·Biochimica Et Biophysica Acta·G TettamantiV Zambotti
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A A IlyasR O Brady

❮ Previous
Next ❯

Citations

May 1, 1996·Muscle & Nerve·L Van den BergN Latov
Apr 15, 2000·Journal of Clinical Apheresis·R Weinstein
Jun 1, 1992·Annals of Neurology·A Pestronk
Sep 15, 1994·Biochimica Et Biophysica Acta·L SvennerholmB M Rynmark
Nov 1, 1995·Journal of the Neurological Sciences·E ManfrediniG Scarlato
Sep 1, 1994·Journal of Neuroimmunology·E Nobile-OrazioG Scarlato
Jun 1, 1994·Journal of Neuroimmunology·M OginoN Latov
Jan 1, 1996·Neuromuscular Disorders : NMD·J T Kissel, J R Mendell
Mar 8, 2005·Journal of Neuroimmunology·Gianluca IsoardoFabio Malavasi
Apr 16, 1992·The New England Journal of Medicine·C J Wrobel, D Watson
Dec 18, 2010·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Madhura A TamhankarMark J Brown
Mar 20, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H C LehmannB C Kieseier
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·T LevineR Choksi
Oct 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·N C NotermansF G Jennekens
May 15, 1994·American Journal of Ophthalmology·M B WaxA Pestronk
Nov 3, 2006·Expert Review of Neurotherapeutics·Yee-Cheun Chan, Einar Wilder-Smith
Mar 1, 2011·Expert Opinion on Emerging Drugs·Efstathios KastritisMeletios A Dimopoulos
Jun 26, 2012·La Revue de médecine interne·M PihanA-V Doncker
May 31, 2011·Journal of Neuroimmunology·Sabrina MatàDiego Minciacchi
Jun 9, 2016·Expert Review of Neurotherapeutics·Jean-Michel VallatStéphane Mathis
Sep 16, 2004·Current Opinion in Neurology·Eduardo Nobile-Orazio
Dec 1, 1989·American Journal of Medical Genetics·W A HortonJ Chou
Jul 7, 2017·Current Opinion in Neurology·Jean-Christophe Antoine, Jean-Philippe Camdessanché
Feb 22, 2018·Journal of Clinical Neuromuscular Disease·Ahmad DaherKarin Woodman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.