Anti-N-methyl-D-aspartate receptor encephalitis during pregnancy
Abstract
To report 3 patients who developed anti-N-methyl-d-aspartate receptor encephalitis during pregnancy. Case reports. University hospitals. Patients Three young women developed at 14, 8, and 17 weeks of gestation acute change of behavior, prominent psychiatric symptoms, progressive decrease of consciousness, seizures, dyskinesias, and autonomic dysfunction. Clinical, radiological, and immunological findings. The 3 patients had cerebrospinal fluid pleocytosis, normal magnetic resonance imaging, and electroencephalogram showing slow activity. All had higher antibody titers in cerebrospinal fluid than in serum and 2 had ovarian teratomas that were removed. The pregnancy was terminated in 1 patient with recurrent bilateral teratomas. All patients had substantial neurological recoveries, and the 2 newborns were normal. Results of extensive antibody testing in 1 of the babies were negative. The current study shows that anti-NMDAR encephalitis during pregnancy can have a good outcome for the mother and newborn.
Citations
A case of NMDAR encephalitis misdiagnosed as postpartum psychosis and neuroleptic malignant syndrome
Human gestational N-methyl-d-aspartate receptor autoantibodies impair neonatal murine brain function
Related Concepts
Related Feeds
Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis is a form of of brain inflammation due to antibodies against NMDA receptors. Discover the latest research on anti-NMDA receptor encephalitis here.
CSF & Lymphatic System
This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.