Anti-N-methyl-D-aspartate receptor encephalitis associated with an ovarian teratoma in an adolescent female

Journal of Pediatric Surgery
Aaron P LesherChristian J Streck

Abstract

Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a recently described paraneoplastic syndrome with prominent neuropsychiatric symptoms. We report a case of NMDA receptor encephalitis in a 15-year-old female related to the development of NMDA receptor autoantibodies triggered by an ovarian teratoma. Removal of the mature teratoma proved curative with eventual resolution of the paraneoplastic disease process and associated psychiatric symptoms. Increasingly, reports of anti-NMDA receptor encephalitis associated with ovarian teratomas in pediatric patients, as well as a novel assay to measure these antibodies, suggest an etiology for this disease process that may be amenable to prompt surgical excision. The clinical presentation, diagnosis, and surgical management of the disease, as well as a review of the literature, are included.

References

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Citations

Dec 17, 2010·Current Neurology and Neuroscience Reports·Elizabeth M Wells, Josep Dalmau
Sep 24, 2015·Molecular Psychiatry·M A Landek-SalgadoA Sawa
Jul 10, 2012·Neurologia i neurochirurgia polska·Ewa MottaArkadiusz Stęposz
Apr 25, 2020·Biomedical Journal·Kuang-Lin Lin, Jann-Jim Lin
Oct 28, 2017·ACS Chemical Neuroscience·Arun Venkatesan, Krishma Adatia

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