Anti-N-methyl-D-aspartate receptor encephalitis: an emerging cause of centrally mediated sinus node dysfunction.

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Tamim M NazifJosé M Dizon

Abstract

Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE) is a recently recognized form of autoimmune encephalitis that typically affects young women, often as a paraneoplastic syndrome related to ovarian teratoma. Clinical features include psychiatric and neurological disturbances, central hypoventilation, autonomic instability, and cardiac dysrhythmias. The prevalence, nature, and outcomes of cardiac dysrhythmias in patients with NMDARE have not been well described. Records of 10 consecutive patients with NMDARE were reviewed to obtain clinical, laboratory, echocardiographic, electrocardiographic, and radiological data. Patients were all female with an average age of 23 ± 5.5 years. Echocardiograms revealed structurally normal hearts with the exception of mild left ventricular hypertrophy in two cases. Eight patients had inappropriate sinus tachycardia. Six patients developed significant sinus bradycardia, which included periods of sinus arrest in four cases. Five patients manifested both sinus bradycardia and tachycardia. Bradycardia was often triggered by identifiable vagal stimuli. Temporary pacing was instituted in three patients, but permanent pacing was not required in any of the patients. Magnetic resonance imaging (MRI...Continue Reading

References

Jan 1, 1987·Intensive Care Medicine·J De KeyserG Ebinger
Mar 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·M B Sundaram, P Siemens
Mar 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·S PollockN Ahmed
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I MatsuoA Takeshita
Aug 24, 2001·Internal Medicine·S IshikawaS Ikeda
May 13, 2005·Brain : a Journal of Neurology·Beau M AncesJosep Dalmau
Sep 24, 2005·Annals of Neurology·Roberta VitalianiJosep Dalmau
Jan 20, 2006·The European Journal of Neuroscience·L B M Resstel, F M A Corrêa
Mar 21, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Belinda K SmithDavid L Prior
May 5, 2007·Nature Clinical Practice. Neurology·Lauren H SansingJosep Dalmau
Nov 29, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H KataokaS Ueno
Feb 27, 2008·Neurology·María Elena Novillo-LópezJaime Masjuan
Apr 11, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H V Schapira
Feb 17, 2009·Autonomic Neuroscience : Basic & Clinical·Fernando H F AlvesFernando M A Correa
Apr 15, 2009·Archives of Neurology·Pitt NiehusmannChristian G Bien
Aug 12, 2009·Annals of Neurology·Nicole R FloranceJosep Dalmau
Sep 1, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M S GableC A Glaser
Sep 26, 2009·Journal of Chemical Neuroanatomy·Li-Hsien Lin
Jul 29, 2010·Pacing and Clinical Electrophysiology : PACE·David NunanDavid A Brodie

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Citations

Jun 20, 2013·Current Neurology and Neuroscience Reports·H Alex ChoiKiwon Lee
Aug 16, 2015·Autonomic Neuroscience : Basic & Clinical·Jung-Ick ByunKon Chu
Dec 31, 2017·Journal of Medical Case Reports·Christopher A OvensAndrew Duggins
Dec 24, 2018·Aging and Disease·Jiahui XuHuirong Liu
Aug 28, 2020·Journal of Community Hospital Internal Medicine Perspectives·Binita BhandariVinod Nookala

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