Sep 23, 2014

Anti-neurotoxicity effects of oxoisoaporphine-lipoic acid hybrids

Chemico-biological Interactions
Wei ChenHuang Tang


Four oxoisoaporphine-lipoic acid hybrids were designed, synthesized, and investigated in this study. To develop the hybrids, the oxoisoaporphine fragment was used for its inhibition of cholinesterases and β-amyloid (Aβ) aggregation, while the unit of lipoic acid was used for its radical-capturing and neuroprotective effects. The hybrids exhibited moderate inhibitory effects on the activity of acetylcholinesterase (AChE), with IC50 values in the micromolar range and low toxicity in SH-SY5Y cells. Moreover, the learning and memory abilities, climbing capability, and average life expectancy of the Aβ42 transgenic Drosophila were all significantly improved by the hybrids. They also enhanced the intracephalic antioxidant activity, the metabolism, and the activity cholinesterase in the flies. More strikingly, Aβ42 aggregation in the hybrids-treated Drosophila was attenuated with effective neuroprotection. Our results indicate the potential of using these oxoisoaporphine-lipoic acid hybrids in AD treatments.

  • References26
  • Citations1


Mentioned in this Paper

Metabolic Process, Cellular
Thiobarbituric Acid Reactive Substances
Familial Alzheimer Disease (FAD)
Sodium Malondialdehyde
Phosphate buffers
Hydrogen Peroxide
Dimethyl Sulfoxide
Central Neuroblastoma

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