PMID: 11924649Apr 2, 2002Paper

Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism

Scandinavian Journal of Rheumatology
Troels HerlinAllan Wiik

Abstract

We describe the ANCA profile of two monozygotic triplets (A and B) treated with propylthiouracil (PTU) for hyperthyroidism who developed LE-like manifestations. Triplet C also developed hyperthyroidism but was not treated with PTU and never experienced LE-like symptoms. Triplet A and B showed a marked rise in P-ANCA titer to 1:1280 after PTU was introduced whereas triplet C never had a titer higher than 1:80. Consecutive sera were investigated for ANCA to six different neutrophil granule proteins. Triplet A and B, but not C, both developed a strongly positive elastase-ANCA. Our results confirm the importance of a genetic factor influencing the susceptibility to drug-induced LE.

Citations

Oct 7, 2005·Arthritis Research & Therapy·Allan Wiik
Jul 22, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Maida WongAntonio La Cava
Feb 19, 2008·Current Opinion in Rheumatology·Allan Wiik
Jun 6, 2012·Nature Reviews. Nephrology·Min ChenMing-Hui Zhao
Feb 15, 2018·Journal of Community Hospital Internal Medicine Perspectives·Aliaksandr Trusau, Michael L Brit
Aug 9, 2003·Expert Opinion on Drug Safety·Mittie K Doyle, Marta L Cuellar
Nov 9, 2004·Pediatric Pulmonology·Anayansi Lasso PirotSuzanne E Beck

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